Technology Process of 1,2,4-Dithiazolidine-4-acetic acid, a-(1-methylethyl)-3,5-dioxo-,
(4-carboxy-2-nitrophenyl)methyl ester, (S)-
There total 7 articles about 1,2,4-Dithiazolidine-4-acetic acid, a-(1-methylethyl)-3,5-dioxo-,
(4-carboxy-2-nitrophenyl)methyl ester, (S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
dichloromethane; trifluoroacetic acid;
at 25 ℃;
for 3h;
DOI:10.1021/ja00303a019
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 89 percent / fuming HNO3 / 1 h / 0 °C
2: 94 percent / acetic acid / 16 h / 100 °C
3: 95 percent / cc.H2SO4 / CHCl3; dioxane / 1.) -78 deg C, 2.) 40-50 deg C, 3 days
4: 94 percent / NH2-NH2 hydrate / CHCl3 / 2 h / 25 °C
5: 60 percent / N,N'-dicyclohexylcarbodiimide / CH2Cl2 / 48 h / 25 °C
6: 90 percent / CH2Cl2; trifluoroacetic acid / 3 h / 25 °C
With
sulfuric acid; nitric acid; hydrazine hydrate; dicyclohexyl-carbodiimide;
In
1,4-dioxane; dichloromethane; chloroform; acetic acid; trifluoroacetic acid;
DOI:10.1021/ja00303a019
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 94 percent / acetic acid / 16 h / 100 °C
2: 95 percent / cc.H2SO4 / CHCl3; dioxane / 1.) -78 deg C, 2.) 40-50 deg C, 3 days
3: 94 percent / NH2-NH2 hydrate / CHCl3 / 2 h / 25 °C
4: 60 percent / N,N'-dicyclohexylcarbodiimide / CH2Cl2 / 48 h / 25 °C
5: 90 percent / CH2Cl2; trifluoroacetic acid / 3 h / 25 °C
With
sulfuric acid; hydrazine hydrate; dicyclohexyl-carbodiimide;
In
1,4-dioxane; dichloromethane; chloroform; acetic acid; trifluoroacetic acid;
DOI:10.1021/ja00303a019
