Propionohydroxamic acid

Base Information

• Chemical Name: Propionohydroxamic acid
• CAS No.: 2580-63-4
• Molecular Formula: C₃H₇NO₂
• Molecular Weight: 89.0941
• Hs Code.: 2924199090
• European Community (EC) Number: 219-946-2
• UNII: 9K8TD4EMP0
• DSSTox Substance ID: DTXSID30180460
• Nikkaji Number: J51.106D
• ChEMBL ID: CHEMBL4303316
• Mol file: 2580-63-4.mol

Synonyms:propionohydroxamic acid

Chemical Property of Propionohydroxamic acid

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 52.82000
• Density: 1.093g/cm³
• LogP: 0.74210
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 89.047678466
• Heavy Atom Count: 6
• Complexity: 52.8

Purity/Quality:

99% ^*data from raw suppliers

Propionohydroxamicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)NO

Technology Process of Propionohydroxamic acid

There total 18 articles about Propionohydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-Nitropropane (108-03-2) → propionohydroxamic acid (2580-63-4,875452-10-1,875452-12-3)

Guidance literature:

With selenium(IV) oxide; triethylamine; In dichloromethane; 1.) 0-10 deg C, 10 min. 2.) 20 deg C, 30 min. 3.) reflux, 1h;

DOI:10.1055/s-1980-29158

Reference yield: 60.0%

propanoic acid methyl ester (554-12-1) → propionohydroxamic acid (2580-63-4,875452-10-1,875452-12-3)

Guidance literature:

With sodium hydroxide; hydroxylamine hydrochloride; In methanol; water; for 1h; Ambient temperature;

Reference yield: 36.0%

Ethyl propionate (105-37-3,20741-13-3) → propionohydroxamic acid (2580-63-4,875452-10-1,875452-12-3)

Guidance literature:

With hydroxylamine; sodium methylate; In methanol; for 16h;

DOI:10.1016/j.bmcl.2012.05.032

upstream raw materials:

propionylcarbamic acid ethyl ester

propionaldehyde

1-Nitropropane

Ethyl propionate

Downstream raw materials:

N-Propionyl-O-trans-cinnamoyl-hydroxylamin

O-benzoyl-N-propionyl-hydroxylamine

O-acetyl-N-propionyl-hydroxylamine