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High purity Methyl propionate TOP1 supplier in China
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USD $ 2.0-2.0 / Gram 100 Gram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality Methyl Propionate supplier in China
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Methyl propionate TOP1 supplier in China
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USD $ 2200.0-2300.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier
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Methyl propionate;
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Methyl Propionate
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USD $ 2.0-3.0 / Kilogram 1 Kilogram 50 Metric Ton/Day EAST CHEMSOURCES LIMITED Contact Supplier
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TIANFUCHEM--554-12-1--Methyl propionate factory price
Cas No: 554-12-1
USD $ 2000.0-2000.0 / Metric Ton 1 Metric Ton 1000 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier

554-12-1 Usage

Hazard

Flammable, dangerous fire risk, explosivelimits in air 2.5–13%.

References

https://en.wikipedia.org/wiki/Methyl_propionate https://pubchem.ncbi.nlm.nih.gov/compound/11124#section=Top https://www.alfa.com/zh-cn/catalog/A14944/

Shipping

UN1248 Methyl propionate, Hazard Class: 3; Labels: 3-Flammable liquid.

Chemical Properties

Methyl propionate has a fruity odor reminiscent of rum. It has a sweet flavor suggestive of black currant

Production Methods

Methyl propionate is produced by the direct esterification of propionic acid with methanol in the presence of concentrated sulfuric acid .

Uses

In organic synthesis.

Chemical Properties

colourless liquid

Chemical Synthesis

By direct esterification of the acid with methanol in the presence of concentrated H2SO4

Occurrence

Reported found in guava, honey, melon, pineapple, raspberry, blackberry, strawberry, cheddar cheese, cooked beef, coffee, soy protein, durian (Durio zibethinus), starfruit, plum brandy, cherimoya, kiwifruit, naranjilla, mussels and rooibus tea (Aspalathus linearis)

Description

Methyl propionate, also known as methyl propanoate, is a chemical compound with the molecular formula C4H8O2. It is a volatile ester with a sweet, fruity, rum-like odor.

Health Hazard

May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Chemical Properties

Methyl propionate is colorless liquid with a sweet, fruity, rum-like odor.

Air & Water Reactions

Highly flammable. Soluble in water.

Incompatibilities

May form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Keep away from heat and moisture.

Safety Profile

Moderately toxic by ingestion. Mildly toxic by inhalation. A skin irritant. A very dangerous fire hazard when exposed to heat, flame, or oxidizers. Explosive in the form of vapor when exposed to heat or flame. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Wash the ester with saturated aqueous NaCl, then dry it with Na2CO3 and distil it from P2O5. (This removes any free acid and alcohol.) It has also been dried with anhydrous CuSO4. [Beilstein 2 IV 104.]

Aroma threshold values

Detection: 100 ppb to 8.8 ppm

Uses

Methyl propionate is used as a solvent for cellulose nitrate and lacquers, and as a raw material for the production of paints, varnishes and other chemicals such as methyl methacrylate. Due to its fruity smell and taste, it is also used in fragrances and flavoring.

Potential Exposure

Used as a solvent; and in making paints, lacquers, and varnishes. Also used in flavorings and fragrances

General Description

A clear colorless liquid. Flash point 28°F. Density about the same as water. Vapors heavier than air. May irritate skin, eyes, and mucous membranes. Used for flavoring and as a solvent.

Reactivity Profile

Methyl propionate reacts with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction with caustic solutions. Flammable hydrogen is generated with alkali metals and hydrides.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Preparation

Methyl propionate can be prepared by esterification of propionic acid with methanol. Industrially, it is prepared by the reaction of ethylene with carbon monoxide and methanol in the presence of nickel carbonyl.

Chemical Properties

Methyl propionate has a fruity odor reminiscent of rum with a sweet flavor suggestive of black currant. May be prepared by direct esterification of the acid with methanol in the presence of concentrated H2S04.

Description

Methyl propionate is an organic compound belonging to the family of carboxylic acid esters, which is commonly applied as a solvent for cellulose nitrate and lacquers. It also serves as a raw material in organic synthesis for manufacturing paints, varnishes and other chemical productions such as methyl methacrylate. Besides, the fruity smell and taste of methyl propanoate results in its usage of fragrances and flavoring agents. Methyl propanoate can be synthesized by esterifying propionic acid with methanol. In the field of industry, it is produced by the reaction of ethylene with carbon monoxide and methanol in the presence of nickel carbonyl.
InChI:InChI=1/C4H8O2/c1-3-4(5)6-2/h3H2,1-2H3

554-12-1 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (A14944)  Methyl propionate, 99%    554-12-1 100ml 312.0CNY Detail
Alfa Aesar (A14944)  Methyl propionate, 99%    554-12-1 500ml 899.0CNY Detail
Alfa Aesar (A14944)  Methyl propionate, 99%    554-12-1 2500ml 4067.0CNY Detail
Sigma-Aldrich (81988)  Methylpropionate  analytical standard 554-12-1 81988-1ML 301.86CNY Detail

554-12-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl propionate

1.2 Other means of identification

Product number -
Other names Propanoic acid, methyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:554-12-1 SDS

554-12-1Synthetic route

methanol
67-56-1

methanol

propionic acid
802294-64-0

propionic acid

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

Conditions
ConditionsYield
With boron trifluoride at 65℃; for 0.333333h;100%
With Dowex 50W×2 hydrogen form at 103 - 108℃; Reagent/catalyst; Autoclave; Large scale;98.6%
With bis(acetylacetonato)dioxidomolybdenum(VI) for 8h; Heating;72%
acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

Conditions
ConditionsYield
With hydrogen; palladium(II) complex of ferrocenylamine sulfide (2) In acetone under 4137.2 Torr; for 0.25h; or with catalyst 3, 0.75 h;100%
With [Ir(1-(1′-methylpyrazole)-3-(4′-methylphenyl)triazenide)Cp*Cl]; isopropyl alcohol at 90℃; for 6h; Catalytic behavior; Reagent/catalyst; Inert atmosphere; Glovebox;99%
With tetrahydroxydiboron; water; sodium hydrogencarbonate In tetrahydrofuran at 60℃; for 8h; Inert atmosphere;99%
ethene
74-85-1

ethene

[PdH(PPh3)3](TsO)

[PdH(PPh3)3](TsO)

carbon monoxide
201230-82-2

carbon monoxide

trans-[Pd(COEt)(OTs)(PPh3)2]
771476-64-3

trans-[Pd(COEt)(OTs)(PPh3)2]

B

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

[Pd(COEt)(PPh3)3](TsO)
1478674-03-1

[Pd(COEt)(PPh3)3](TsO)

Conditions
ConditionsYield
at -80.16 - 49.84℃; under 3000.3 Torr; for 0.0133333h;A 0.1%
B 100%
C n/a
methanol
67-56-1

methanol

ethene
74-85-1

ethene

carbon monoxide
201230-82-2

carbon monoxide

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

Conditions
ConditionsYield
With methanesulfonic acid; palladium diacetate; bis(phosphaadamantyl)diphosphine at 90℃;99%
With α,α′-bis(2-pyridyl(tert-butyl)phosphino)-o-xylene; palladium dichloride at 80℃; under 15001.5 - 22502.3 Torr; for 20h; Reagent/catalyst; Pressure; Inert atmosphere; Autoclave;99%
With bis(acetylacetonato)palladium(II); 1,1’-ferrocenediyl-bis(tert-butyl(pyridin-2-yl)phosphine); toluene-4-sulfonic acid at 80℃; for 0.166667h; Catalytic behavior; Reagent/catalyst; Temperature; Autoclave; Inert atmosphere;99%
methanol
67-56-1

methanol

trans-[Pd(COEt)(OTs)(PPh3)2]
771476-64-3

trans-[Pd(COEt)(OTs)(PPh3)2]

carbon monoxide
201230-82-2

carbon monoxide

trans-[Pd(COOMe)(OTs)(PPh3)2]
771476-65-4

trans-[Pd(COOMe)(OTs)(PPh3)2]

B

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

Conditions
ConditionsYield
With toluene-4-sulfonic acid; triphenylphosphine In methanol Pd complex, (0.1 mmol) reacted with MeOH containing PPh3 (0.1 mmol) + p-toluenesulfonic acid (0.1 mmol) satd. with CO (ca. 20 min); pptd. with cold H2O; suspn. filtered; ppt. washed with cold H2O; dried (vac.);A 90%
B 99%
methanol
67-56-1

methanol

formaldehyd
50-00-0

formaldehyd

ethene
74-85-1

ethene

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

Conditions
ConditionsYield
With palladium diacetate; toluene-4-sulfonic acid; 1,2-bis[di(t-butyl)phosphinomethyl]benzene at 100℃; under 3750.38 Torr; for 20h; Inert atmosphere; Autoclave; regioselective reaction;99%
propionic acid
802294-64-0

propionic acid

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

Conditions
ConditionsYield
With triethylamine at 160℃; for 5h; Autoclave; Green chemistry;98%
With diiron nonacarbonyl at 180℃; for 1h; Sealed tube;
propynoic acid methyl ester
922-67-8

propynoic acid methyl ester

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

Conditions
ConditionsYield
With tetrahydroxydiboron; water; sodium hydrogencarbonate In methanol at 80℃; for 12h;98%
methanol
67-56-1

methanol

1,1'-(2-oxoimidazolidine-1,3-diyl)bis(propan-1-one)
40424-08-6

1,1'-(2-oxoimidazolidine-1,3-diyl)bis(propan-1-one)

A

imidazolidone
120-93-4

imidazolidone

B

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

Conditions
ConditionsYield
With C17H23BN2O at 50℃; under 760.051 Torr; for 15h; Inert atmosphere; chemoselective reaction;A 97%
B n/a
methanol
67-56-1

methanol

1,1'-(2-oxoimidazolidine-1,3-diyl)bis(propan-1-one)
40424-08-6

1,1'-(2-oxoimidazolidine-1,3-diyl)bis(propan-1-one)

A

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

B

1-propionyl-2-oxo-imidazolidine
55150-33-9

1-propionyl-2-oxo-imidazolidine

Conditions
ConditionsYield
With C17H23BN2O at 25℃; under 760.051 Torr; for 0.25h; Inert atmosphere; chemoselective reaction;A n/a
B 96%
2-chloro-propionic acid methyl ester
17639-93-9

2-chloro-propionic acid methyl ester

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

Conditions
ConditionsYield
With sodium chloride; tin(ll) chloride In tetrahydrofuran; water for 2h; Heating; further sodium halides or pseudo-halides and metal halides;95%
With sodium hydrogensulfide; tin(ll) chloride In tetrahydrofuran; water for 2h; Heating;95%
With sodium iodide; tin(ll) chloride In tetrahydrofuran; water for 2h; Heating;92%
With sodium tetrahydroborate; tin(ll) chloride In tetrahydrofuran for 2h; Heating;90%
methanol
67-56-1

methanol

3,4-dichloro-(E)-3-hexene
51430-68-3

3,4-dichloro-(E)-3-hexene

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

Conditions
ConditionsYield
With ozone at -40℃; for 43h;92%
ethene
74-85-1

ethene

Methyl formate
107-31-3

Methyl formate

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

Conditions
ConditionsYield
With ruthenium trichloride; tetraethylammonium iodide; bis(triphenylphosphine)iminium chloride In N,N-dimethyl-formamide at 165℃; under 18751.9 Torr; for 5h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Autoclave;85.4%
With ruthenium trichloride; tetraethylammonium iodide In N,N-dimethyl-formamide at 190℃; under 45003.6 Torr; for 1h; Product distribution; var. solvents, reaction times, promoters, and ruthenium complexes, also in the presence of CO;
With tris(triphenylphosphine)ruthenium(II) chloride at 190 - 200℃; under 7500.6 Torr; for 18h; Product distribution; other alkyl formate; var. solvents, var. substrates concentrations;
With 1-butyl-1-methylpyrrolidinium chloride; dicobalt octacarbonyl; dichlorotricarbonylruthenium(II) dimer at 120℃; under 15001.5 Torr; for 15h; Product distribution / selectivity;
[DBUH][O2COMe]

[DBUH][O2COMe]

propionic acid anhydride
123-62-6

propionic acid anhydride

A

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

B

1,8-diazabicyclo[5.4.0]undec-7-enium propanoate
51301-57-6

1,8-diazabicyclo[5.4.0]undec-7-enium propanoate

Conditions
ConditionsYield
In methanol at 20℃; for 1h;A 85%
B n/a
Dimethoxymethane
109-87-5

Dimethoxymethane

propionic acid anhydride
123-62-6

propionic acid anhydride

A

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

B

propionic acid methoxymethyl ester
70767-92-9

propionic acid methoxymethyl ester

Conditions
ConditionsYield
With Amberlyst 15 at 50 - 55℃; for 0.0833333h; Heating / reflux;A n/a
B 83.6%
methanol
67-56-1

methanol

propionaldehyde
123-38-6

propionaldehyde

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

Conditions
ConditionsYield
With sodium carbonate; N,N'-diiodo-N,N'-1,2-ethanediylbis(p-toluenesulphonamide) at 20℃; for 40h;80%
With magnesium hydroxide; oxygen at 90℃; under 2250.23 Torr; for 2h;
acetic anhydride
108-24-7

acetic anhydride

2-Pentanone
107-87-9

2-Pentanone

A

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

B

butanoic acid methyl ester
623-42-7

butanoic acid methyl ester

Conditions
ConditionsYield
With oxygen; manganese(III) triacetate dihydrate at 90℃; under 3750.38 Torr; for 10h; Autoclave;A 21%
B 79%
butanone
78-93-3

butanone

A

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

B

ethyl acetate
141-78-6

ethyl acetate

Conditions
ConditionsYield
With hydrogenchloride In chloroform at 20℃; for 14h; Baeyer-Villiger oxidation;A 14%
B 78%
With (η5-C5H4SiMe3)2NbH(O)C=CPh2 at 25℃;
With sec-decanepersulfonic acid In acetonitrile at 17℃; Rate constant;
methyl lactate
547-64-8

methyl lactate

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

Conditions
ConditionsYield
With hydrogen In methanol at 220℃; under 37503.8 Torr; for 12h; Reagent/catalyst;77%
With nickel(II) ferrite; hydrogen In methanol at 220℃; under 37503.8 Torr; for 12h; Catalytic behavior; Reagent/catalyst; Temperature;75%
trans-MeOIr(CO)(PPh3)2
94070-38-9

trans-MeOIr(CO)(PPh3)2

acetaldehyde
75-07-0

acetaldehyde

A

HIr(PPh3)2(CO)2
17250-59-8

HIr(PPh3)2(CO)2

B

acetic acid methyl ester
79-20-9

acetic acid methyl ester

C

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

Conditions
ConditionsYield
In cyclohexane in dry box onto the degassed (vac.) soln. of complex (in a pressure tube fitted with a Teflon stopcock) CH3CHO distilled, 5 d reacted at room temp.; not isolated, spect. detection by IR and NMR in the soln.;A n/a
B 75%
C n/a
methanol
67-56-1

methanol

[hydroxy(tosyloxy)iodo]benzene
27126-76-7

[hydroxy(tosyloxy)iodo]benzene

propionic acid anhydride
123-62-6

propionic acid anhydride

A

iodobenzene
591-50-4

iodobenzene

B

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

C

methyl 2-{[(4-methylphenyl)sulfonyl]oxy}propanoate
66648-29-1

methyl 2-{[(4-methylphenyl)sulfonyl]oxy}propanoate

Conditions
ConditionsYield
Stage #1: [hydroxy(tosyloxy)iodo]benzene; propionic acid anhydride at 100℃; for 0.333333h;
Stage #2: methanol With toluene-4-sulfonic acid for 4h; Heating;
A n/a
B n/a
C 73%
tri(1-naphthyl)phosphonium tris(pentafluorophenyl)borohydride

tri(1-naphthyl)phosphonium tris(pentafluorophenyl)borohydride

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

A

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

B

C34H28O2P(1+)

C34H28O2P(1+)

Conditions
ConditionsYield
In dichloromethane-d2 for 12h; Glovebox; Sealed tube;A 28%
B 72%
dimethylsulfite
616-42-2

dimethylsulfite

propionic acid
802294-64-0

propionic acid

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

Conditions
ConditionsYield
sulfuric acid Heating;70%
methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

ethylmercuric acetate
109-62-6

ethylmercuric acetate

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

Conditions
ConditionsYield
With Wilkinson's catalyst at 65 - 100℃; under 5171.5 - 25857.4 Torr;66%
methanol
67-56-1

methanol

propionic acid anhydride
123-62-6

propionic acid anhydride

(mesyloxyhydroxyiodo)benzene
105551-42-6

(mesyloxyhydroxyiodo)benzene

A

iodobenzene
591-50-4

iodobenzene

B

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

C

methyl 2-((methanesulfonyl)oxy)propanoate

methyl 2-((methanesulfonyl)oxy)propanoate

Conditions
ConditionsYield
Stage #1: propionic acid anhydride; (mesyloxyhydroxyiodo)benzene at 100℃; for 0.333333h;
Stage #2: methanol With toluene-4-sulfonic acid for 4h; Heating;
A n/a
B n/a
C 66%
methanol
67-56-1

methanol

propionic acid anhydride
123-62-6

propionic acid anhydride

{hydroxy[(+)-10-camphosulfonyloxy]iodo}benzene

{hydroxy[(+)-10-camphosulfonyloxy]iodo}benzene

A

iodobenzene
591-50-4

iodobenzene

B

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

C

methyl 2-[(+)-camphorsulfonyloxy]propionate

methyl 2-[(+)-camphorsulfonyloxy]propionate

Conditions
ConditionsYield
Stage #1: propionic acid anhydride; {hydroxy[(+)-10-camphosulfonyloxy]iodo}benzene at 100℃; for 0.333333h;
Stage #2: methanol With toluene-4-sulfonic acid for 4h; Heating;
A n/a
B n/a
C 62%
methyl lactate
547-64-8

methyl lactate

A

propan-1-ol
71-23-8

propan-1-ol

B

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

Conditions
ConditionsYield
With hydrogen In methanol at 220℃; under 37503.8 Torr; for 12h;A 10%
B 60%
methanol
67-56-1

methanol

methylpropioimidate hydrochloride
39739-45-2

methylpropioimidate hydrochloride

A

trimethoxypropane
24823-81-2

trimethoxypropane

B

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

Conditions
ConditionsYield
at 20℃; for 48h;A 59%
B n/a
tri(o-tolyl)phosphonium tris(pentafluorophenyl)borohydride
1094249-99-6

tri(o-tolyl)phosphonium tris(pentafluorophenyl)borohydride

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

A

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

B

C25H28O2P(1+)

C25H28O2P(1+)

Conditions
ConditionsYield
In dichloromethane-d2 for 12h; Glovebox; Sealed tube;A 47%
B 53%
methyl pyrazine-2-carboxylate
6164-79-0

methyl pyrazine-2-carboxylate

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

methyl 2-methyl-3-(pyrazin-2-yl)-3-oxopropionate
324737-10-2

methyl 2-methyl-3-(pyrazin-2-yl)-3-oxopropionate

Conditions
ConditionsYield
Stage #1: methyl pyrazine-2-carboxylate With sodium hydride In toluene at 15 - 25℃; for 0.5h; Industrial scale;
Stage #2: propanoic acid methyl ester In methanol; toluene at 15 - 40℃; Temperature; Solvent; Reagent/catalyst; Industrial scale;
100%
Stage #1: propanoic acid methyl ester With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: methyl pyrazine-2-carboxylate In tetrahydrofuran at 0 - 25℃; for 3.5h;
Stage #3: With ammonium chloride In tetrahydrofuran for 0.5h;
89%
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 5h; Inert atmosphere;79%
With NaH; ammonium chloride In toluene
propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

(2R,6R)-6-[(methoxymethoxy)methyl]-1-(phenylmethyl)-2-[3-[[tris(1-methylethyl)silyl]oxy]propyl]-2-piperidinecarboxaldehyde

(2R,6R)-6-[(methoxymethoxy)methyl]-1-(phenylmethyl)-2-[3-[[tris(1-methylethyl)silyl]oxy]propyl]-2-piperidinecarboxaldehyde

(2R,6R)-β-hydroxy-6-[(methoxymethoxy)methyl]-α-methyl-1-(phenylmethyl)-2-[3-[[tris(1-methylethyl)silyl]oxy]propyl]-2-piperidinepropanoic acid methyl ester

(2R,6R)-β-hydroxy-6-[(methoxymethoxy)methyl]-α-methyl-1-(phenylmethyl)-2-[3-[[tris(1-methylethyl)silyl]oxy]propyl]-2-piperidinepropanoic acid methyl ester

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran at -78℃;99%
Stage #1: propanoic acid methyl ester With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 1.33333h;
Stage #2: (2R,6R)-6-[(methoxymethoxy)methyl]-1-(phenylmethyl)-2-[3-[[tris(1-methylethyl)silyl]oxy]propyl]-2-piperidinecarboxaldehyde In tetrahydrofuran; hexane at -78℃; for 0.75h; Aldol condensation;
Stage #3: With ammonium chloride In tetrahydrofuran; hexane
36%
cyclohexanespiro-2'-(imidazolidin-4'-thione)-5'-spirocyclohexane
4833-50-5

cyclohexanespiro-2'-(imidazolidin-4'-thione)-5'-spirocyclohexane

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

C17H26N2O2S

C17H26N2O2S

Conditions
ConditionsYield
In chloroform-d1 at 20 - 45℃; for 96h;99%
C11H18N2O2S

C11H18N2O2S

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

C15H22N2O4S

C15H22N2O4S

Conditions
ConditionsYield
In chloroform-d1 at 20 - 45℃; for 112h;99%
propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

acetone oxime
127-06-0

acetone oxime

O-propanoyl acetone oxime

O-propanoyl acetone oxime

Conditions
ConditionsYield
With sodium methylate at 70℃; under 760.051 Torr; for 8h; Temperature; Reagent/catalyst; Large scale;98.2%
propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

1-dodecyl alcohol
112-53-8

1-dodecyl alcohol

1-dodecyl propionate
6221-93-8

1-dodecyl propionate

Conditions
ConditionsYield
cerium (IV) sulfate; silica gel for 1h; Heating;98%
propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

2,2'-[1,2-ethanediylbis(oxy)]bisethanol
112-27-6

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

triethylene glycol dipropionate
141-34-4

triethylene glycol dipropionate

Conditions
ConditionsYield
With potassium carbonate at 90 - 95℃;98%
1-(4-methoxy-3-(trifluoromethyl)phenyl)ethanone
149105-10-2

1-(4-methoxy-3-(trifluoromethyl)phenyl)ethanone

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

1-(4-methoxy-3-(trifluoromethyl)phenyl)pentane-1,3-dione

1-(4-methoxy-3-(trifluoromethyl)phenyl)pentane-1,3-dione

Conditions
ConditionsYield
Stage #1: 1-[4-Methoxy-3-(trifluoromethyl)phenyl]ethanone With sodium hydride In diethyl ether; mineral oil at 0℃; for 0.5h;
Stage #2: propanoic acid methyl ester In diethyl ether; mineral oil at 40℃; for 12h;
97%
propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

(RS)-N-tert-butanesulfinyl-(3,3,3)-trifluoroacetaldimine
1219607-85-8

(RS)-N-tert-butanesulfinyl-(3,3,3)-trifluoroacetaldimine

methyl (2S,3S,2'R)-4,4,4-trifluoro-3-(tert-butylsulfinamino)-2-methylbutyrate

methyl (2S,3S,2'R)-4,4,4-trifluoro-3-(tert-butylsulfinamino)-2-methylbutyrate

Conditions
ConditionsYield
Stage #1: propanoic acid methyl ester With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -80℃; for 0.5h;
Stage #2: With triisopropoxytitanium(IV) chloride In tetrahydrofuran; hexane at -80℃; for 0.666667h;
Stage #3: (RS)-N-tert-butanesulfinyl-(3,3,3)-trifluoroacetaldimine In tetrahydrofuran; hexane at -80℃; for 3h; diastereoselective reaction;
96.5%
propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

(RS,E)-N-ethylidene-2-methylpropane-2-sulfinamide
220315-18-4

(RS,E)-N-ethylidene-2-methylpropane-2-sulfinamide

(RS,2S,3R)-(-)-methyl 3-(N-tert-butanesulfinyl)amino-2-methylbutanoate
220315-34-4

(RS,2S,3R)-(-)-methyl 3-(N-tert-butanesulfinyl)amino-2-methylbutanoate

Conditions
ConditionsYield
Stage #1: propanoic acid methyl ester With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: With triisopropoxytitanium(IV) chloride In tetrahydrofuran at -78℃; for 0.5h;
Stage #3: (RS,E)-N-ethylidene-2-methylpropane-2-sulfinamide In tetrahydrofuran at -78℃; for 3h; Further stages.;
96%
With triisopropoxytitanium(IV) chloride; lithium diisopropyl amide In tetrahydrofuran at -78℃;92%
propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

(S)-2-methylpropane-2-sulfinamide
343338-28-3

(S)-2-methylpropane-2-sulfinamide

C8H17NO2S

C8H17NO2S

Conditions
ConditionsYield
With toluene-4-sulfonic acid at 103℃; Inert atmosphere; Schlenk technique;96%
ethyl oleate
6512-99-8

ethyl oleate

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

octadec-9-enoic acid methyl ester
112-62-9

octadec-9-enoic acid methyl ester

Conditions
ConditionsYield
titanium(IV) tetraethanolate for 86h; Heating;95%
propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

2-(2-cyclobutanonyl)-6-bromo-3,4-dihydronaphthalene
76042-40-5

2-(2-cyclobutanonyl)-6-bromo-3,4-dihydronaphthalene

2-(6-bromo-3,4-dihydronaphthalen-2-yl)-1-(1-(carbmethoxy)ethyl)cyclobutanol
76042-59-6

2-(6-bromo-3,4-dihydronaphthalen-2-yl)-1-(1-(carbmethoxy)ethyl)cyclobutanol

Conditions
ConditionsYield
With lithium diisopropyl amide In diethyl ether at -10℃;95%
propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

α-Methyl-4-chlorzimtsaeure-methylester
53059-73-7

α-Methyl-4-chlorzimtsaeure-methylester

Conditions
ConditionsYield
With P(i-BuNCH2CH2)3N at 50℃; for 6h;95%
propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

methyl 3,5-dimethyl-4-[(1'-iodo-2',2'-dimethyl)propyl]pyrrole-2-carboxylate
493006-19-2

methyl 3,5-dimethyl-4-[(1'-iodo-2',2'-dimethyl)propyl]pyrrole-2-carboxylate

methyl 3,5-dimethyl-4-[2',2'-dimethyl-1'-(1

methyl 3,5-dimethyl-4-[2',2'-dimethyl-1'-(1"-methoxycarbonylethyl)propyl]-1H-pyrrole-2-carboxylate

Conditions
ConditionsYield
Stage #1: propanoic acid methyl ester With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 1h;
Stage #2: methyl 3,5-dimethyl-4-[(1'-iodo-2',2'-dimethyl)propyl]pyrrole-2-carboxylate With N,N,N,N,N,N-hexamethylphosphoric triamide In tetrahydrofuran; hexane at -78 - -55℃;
95%
propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

(SS)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide

(SS)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide

methyl (2R,3R,2'S)-4,4,4-trifluoro-3-(tert-butylsulfinamino)-2-methylbutyrate

methyl (2R,3R,2'S)-4,4,4-trifluoro-3-(tert-butylsulfinamino)-2-methylbutyrate

Conditions
ConditionsYield
Stage #1: propanoic acid methyl ester With n-butyllithium; diisopropylamine In diethyl ether; hexane at -80℃; for 0.5h;
Stage #2: With triisopropoxytitanium(IV) chloride In diethyl ether; hexane at -80℃; for 0.666667h;
Stage #3: (SS)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide In diethyl ether; hexane at -80℃; for 3h; diastereoselective reaction;
95%
propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

2-(2-cyclobutanonyl)-6-methoxy-3,4-dihydronaphthalene
76042-39-2

2-(2-cyclobutanonyl)-6-methoxy-3,4-dihydronaphthalene

2-[1-Hydroxy-2-(6-methoxy-3,4-dihydro-naphthalen-2-yl)-cyclobutyl]-propionic acid methyl ester
76043-11-3

2-[1-Hydroxy-2-(6-methoxy-3,4-dihydro-naphthalen-2-yl)-cyclobutyl]-propionic acid methyl ester

Conditions
ConditionsYield
With lithium diisopropyl amide In diethyl ether at -10℃;94%
propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

dimethylaminobis(trifluoromethyl)borane
105224-90-6

dimethylaminobis(trifluoromethyl)borane

1-methoxycarbonylethyl-bis(trifluoromethyl)borane-dimethylamine
148298-53-7

1-methoxycarbonylethyl-bis(trifluoromethyl)borane-dimethylamine

Conditions
ConditionsYield
In pentane dropwise addn. of (CF3)2BNMe2 to a stirred soln. of the carbonyl compound in dry pentane at 4°C; warmed to room temp. with stirring (1 h);; removal of solvent and volatile by-products in vac. at room temp., purifn. by sublimation in vac.; elem. anal.;;94%
propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

[iridium(I)(2,6-bis{(di-tert-butylphosphino)methyl}pyridine)(cyclooctene)](tetrafluoroborate)
913335-50-9

[iridium(I)(2,6-bis{(di-tert-butylphosphino)methyl}pyridine)(cyclooctene)](tetrafluoroborate)

[iridium(I)(2,6-bis{(di-tert-butylphosphino)methyl}pyridine)(H)(methylpropanoate(-H))](tetrafluoroborate)

[iridium(I)(2,6-bis{(di-tert-butylphosphino)methyl}pyridine)(H)(methylpropanoate(-H))](tetrafluoroborate)

Conditions
ConditionsYield
at 60℃; for 20h; Inert atmosphere; Schlenk technique;94%

554-12-1Upstream product

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