Ribalinine

Base Information

Chemical Name:Ribalinine
CAS No.:7688-58-6
Molecular Formula:C₁₅H₁₇NO₃
Molecular Weight:259.305
Hs Code.:2934999090
DSSTox Substance ID:DTXSID20998177
Nikkaji Number:J13.934C
Wikidata:Q104403695
Mol file:7688-58-6.mol

Synonyms:(S)-(-)-Ribalinine;DTXSID20998177;(3S)-3-hydroxy-2,2,10-trimethyl-3,4-dihydropyrano[2,3-b]quinolin-5-one;AKOS040753757

Suppliers and Price of Ribalinine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of Ribalinine

Chemical Property:

Vapor Pressure:6.72E-07mmHg at 25°C
Melting Point:232-233 °C(Solv: acetone (67-64-1))
Boiling Point:393.5°Cat760mmHg
PKA:13.54±0.40(Predicted)
Flash Point:191.8°C
PSA：51.46000
Density:1.28g/cm³
LogP:1.61290
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:259.12084340
Heavy Atom Count:19
Complexity:441

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(C(CC2=C(O1)N(C3=CC=CC=C3C2=O)C)O)C
Isomeric SMILES:CC1([C@H](CC2=C(O1)N(C3=CC=CC=C3C2=O)C)O)C
Description A further pyranoquinolone alkaloid found in the trunk bark of Balfourodendron riedelianum (Engler) Engler, the base may be recrystallized from MeOH-diiso_x0002_propyl ether or EtOH when it forms colourless prisms from the former and irregularly-shaped crystals from the latter. The ultraviolet spectrum in neutral solution (EtOH) has absorption maxima at 237,314 and 326 mf.1, while in acid solution (0.3 N/HCl) there are two maxima at 236 and 300 mf.1. The structure has been established as 3:4: S: 1 0-tetrahydro-3-hydroxy-2:2 :20-trimethyl-S-oxo- 2H-pyrano 2,3-b quinolone.

Technology Process of Ribalinine

There total 7 articles about Ribalinine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 72855-84-6
(+)-(3S)-geibalansine

: 74-88-4
methyl iodide

: 7688-58-6
ribalinine

Guidance literature:: Heating;
DOI:10.1039/c39940000153

Reference yield:

: 88148-18-9
5-methoxy-2,2-dimethyl-(2H)-pyrano<2,3-b>quinoline

: 7688-58-6
ribalinine

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / N-bromosuccinimide; water / tetrahydrofuran / 24 h / 20 °C

2: 40 percent

3: 81 percent / t-BuOK / tetrahydrofuran / 24 h / 20 °C

4: 78 percent / 10percent Pd/C / methanol / 20 °C

5: 97 percent / 15 h / Heating

With N-Bromosuccinimide; potassium tert-butylate; water; 10percent Pd/C; In tetrahydrofuran; methanol; 1: Addition / 2: Acylation / 3: Epoxidation / 4: Catalytic hydrogenation / 5: Methylation;
DOI:10.1039/b005285j

Reference yield:

: (+/-)-trans-3-bromo-4-hydroxy-3,4-dihydro-5-methoxy-2,2-dimethyl-2H-pyrano[2,3-b]quinoline

: 7688-58-6
ribalinine

Guidance literature:: Multi-step reaction with 4 steps

1: 40 percent

2: 81 percent / t-BuOK / tetrahydrofuran / 24 h / 20 °C

3: 78 percent / 10percent Pd/C / methanol / 20 °C

4: 97 percent / 15 h / Heating

With potassium tert-butylate; 10percent Pd/C; In tetrahydrofuran; methanol; 1: Acylation / 2: Epoxidation / 3: Catalytic hydrogenation / 4: Methylation;
DOI:10.1039/b005285j