Benzene, 1-(chloromethyl)-4-methoxy-2-[[4-(methylsulfonyl)phenyl]thio]-

Base Information

• Chemical Name: Benzene, 1-(chloromethyl)-4-methoxy-2-[[4-(methylsulfonyl)phenyl]thio]-
• CAS No.: 98190-63-7
• Molecular Formula: C₁₅H₁₅ClO₃S₂
• Molecular Weight: 342.867
• Mol file: 98190-63-7.mol

Synonyms:

Chemical Property of Benzene, 1-(chloromethyl)-4-methoxy-2-[[4-(methylsulfonyl)phenyl]thio]-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, 1-(chloromethyl)-4-methoxy-2-[[4-(methylsulfonyl)phenyl]thio]-

There total 10 articles about Benzene, 1-(chloromethyl)-4-methoxy-2-[[4-(methylsulfonyl)phenyl]thio]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methanesulfonyl-4-nitrobenzene (2976-30-9) → 1-Chloromethyl-2-(4-methanesulfonyl-phenylsulfanyl)-4-methoxy-benzene (98190-63-7)

Guidance literature:

Multi-step reaction with 7 steps

1: 24 percent / charcoal, FeCl₃*6H₂O, N₂H₄*H₂O / ethanol / 4 h / Heating; standing 2 weeks

2: 1) HCl, NaNO₂, 2) potassium ethyl xanthate, Na₂CO₃ / 1) H₂O, 0 to 2 deg C, 30 min, 2) 40 deg C, 30 min

3: 86 percent / K₂CO₃, Cu / dimethylformamide / 5 h / 140 °C

4: 82 percent / SOCl₂ / pyridine / 6 h / Heating

5: 85 percent / 5 h / Heating

6: 88 percent / NaBH₄, BF₃*O(C₂H₅)2 / tetrahydrofuran / r.t., 5 h, reflux, 2 h

7: HCl / 0.5 h / 60 - 70 °C

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; boron trifluoride diethyl etherate; potassium ethyl xanthogenate; iron(III) chloride; copper; sodium carbonate; potassium carbonate; pyrographite; hydrazine hydrate; sodium nitrite; In tetrahydrofuran; pyridine; ethanol; N,N-dimethyl-formamide;

DOI:10.1135/cccc19850519

Reference yield:

4-bromoohenyl methyl sulfone (3466-32-8) → 1-Chloromethyl-2-(4-methanesulfonyl-phenylsulfanyl)-4-methoxy-benzene (98190-63-7)

Guidance literature:

Multi-step reaction with 7 steps

1: 75 percent / aq. NH₃ / 20 h / 200 - 210 °C / 1) autoclave; 2) standing 48 h,

2: 1) HCl, NaNO₂, 2) potassium ethyl xanthate, Na₂CO₃ / 1) H₂O, 0 to 2 deg C, 30 min, 2) 40 deg C, 30 min

3: 86 percent / K₂CO₃, Cu / dimethylformamide / 5 h / 140 °C

4: 82 percent / SOCl₂ / pyridine / 6 h / Heating

5: 85 percent / 5 h / Heating

6: 88 percent / NaBH₄, BF₃*O(C₂H₅)2 / tetrahydrofuran / r.t., 5 h, reflux, 2 h

7: HCl / 0.5 h / 60 - 70 °C

With hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; thionyl chloride; boron trifluoride diethyl etherate; potassium ethyl xanthogenate; copper; sodium carbonate; potassium carbonate; sodium nitrite; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide;

DOI:10.1135/cccc19850519

Reference yield:

4-methanesulfonylphenylamine (5470-49-5) → 1-Chloromethyl-2-(4-methanesulfonyl-phenylsulfanyl)-4-methoxy-benzene (98190-63-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 1) HCl, NaNO₂, 2) potassium ethyl xanthate, Na₂CO₃ / 1) H₂O, 0 to 2 deg C, 30 min, 2) 40 deg C, 30 min

2: 86 percent / K₂CO₃, Cu / dimethylformamide / 5 h / 140 °C

3: 82 percent / SOCl₂ / pyridine / 6 h / Heating

4: 85 percent / 5 h / Heating

5: 88 percent / NaBH₄, BF₃*O(C₂H₅)2 / tetrahydrofuran / r.t., 5 h, reflux, 2 h

6: HCl / 0.5 h / 60 - 70 °C

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; boron trifluoride diethyl etherate; potassium ethyl xanthogenate; copper; sodium carbonate; potassium carbonate; sodium nitrite; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide;

DOI:10.1135/cccc19850519

upstream raw materials:

4-Methoxy-2-(4-methylsulfonylphenylthio)benzyl Alcohol

1-methanesulfonyl-4-nitrobenzene

4-bromoohenyl methyl sulfone

4-(methylsulfonyl)benzenethiol

Downstream raw materials:

<4-Methoxy-2-(4-methylsulfonylphenylthio)phenyl>acetonitrile

<4-Methoxy-2-(4-methylsulfonylphenylthio)phenyl>acetic Acid

Refernces