(1-Aminocyclohexyl)methanol hydrochloride

Base Information

• Chemical Name: (1-Aminocyclohexyl)methanol hydrochloride
• CAS No.: 5460-68-4
• Molecular Formula: C7H15NO
• Molecular Weight: 165.663
• Hs Code.: 2922199090
• European Community (EC) Number: 830-391-0
• NSC Number: 18892
• Mol file: 5460-68-4.mol

Synonyms:(1-aminocyclohexyl)methanol hydrochloride;5460-68-4;(1-aminocyclohexyl)methanol;hydrochloride;MFCD11505635;(1-AMINOCYCLOHEXYL)METHANOL HCL;(1-Amino cyclohexyl) methanol hydrochloride;(1-Amino cyclohexyl)methanol hydrochloride;SCHEMBL6026561;NEPOOMVFQWOTOW-UHFFFAOYSA-N;NSC18892;NSC-18892;chlorine;AKOS015847820;AKOS015916455;AT12681;SB85101;(1-aminocyclohexyl)methanolhydrochloride;BS-49333;SY178969;(1-amino-cyclohexyl)-methanol hydrochloride;DB-071873;CS-0146523;EN300-40958;A830263;Z2417556977

Chemical Property of (1-Aminocyclohexyl)methanol hydrochloride

Chemical Property:

• Vapor Pressure: 0.0397mmHg at 25°C
• Melting Point: 162-164℃
• Boiling Point: 212°Cat760mmHg
• Flash Point: 82°C
• PSA: 46.25000
• Density: 0.986g/cm³
• LogP: 2.14260
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 165.0920418
• Heavy Atom Count: 10
• Complexity: 86.9

Purity/Quality:

99% ^*data from raw suppliers

(1-Aminocyclohexyl)methanolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)(CO)N.Cl

Technology Process of (1-Aminocyclohexyl)methanol hydrochloride

There total 4 articles about (1-Aminocyclohexyl)methanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

→ 1-(1-aminocyclohexyl)methanol hydrochloride (5460-68-4)

Guidance literature:

With hydrogenchloride; water; for 18h;

Reference yield: 80.0%

1-[1-(tert-butoxycarbonylamino)cyclohexyl]methanol (187610-67-9) → 1-(1-aminocyclohexyl)methanol hydrochloride (5460-68-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

DOI:10.1021/jm0311285

Reference yield:

1-aminocyclohexane carboxylic acid (2756-85-6) → 1-(1-aminocyclohexyl)methanol hydrochloride (5460-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LiAlH₄ / tetrahydrofuran / 28 h / 70 - 80 °C

1.2: 68 percent / TEA / methanol / 4 h / 20 °C

2.1: 80 percent / HCl / dioxane / 1 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jm0311285

upstream raw materials:

1-[1-(tert-butoxycarbonylamino)cyclohexyl]methanol

1-aminocyclohexane carboxylic acid

N-(1-hydroxymethyl-cyclohexyl)-formamide

Downstream raw materials:

1-benzyl-4-(1-hydroxymethylcyclohexyl)piperazine

1-[N-(tert-butoxycarbonyl)-4-chloro-D-phenylalanyl]-4-[1-(1,2,4-triazol-1-yl-methyl)cyclohexyl]piperazine

methanesulfonic acid 1-(4-benzyl-piperazin-1-yl)-cyclohexylmethyl ester

1-benzyl-4-[1-(1,2,4-triazol-1-yl-methyl)cyclohexyl]piperazine