methanesulfonic acid 1-(4-benzyl-piperazin-1-yl)-cyclohexylmethyl ester

Base Information

Chemical Name:methanesulfonic acid 1-(4-benzyl-piperazin-1-yl)-cyclohexylmethyl ester
CAS No.:1026858-98-9
Molecular Formula:C₁₉H₃₀N₂O₃S
Molecular Weight:366.525
Hs Code.:

Synonyms:methanesulfonic acid 1-(4-benzyl-piperazin-1-yl)-cyclohexylmethyl ester

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Chemical Property of methanesulfonic acid 1-(4-benzyl-piperazin-1-yl)-cyclohexylmethyl ester

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Technology Process of methanesulfonic acid 1-(4-benzyl-piperazin-1-yl)-cyclohexylmethyl ester

There total 5 articles about methanesulfonic acid 1-(4-benzyl-piperazin-1-yl)-cyclohexylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 766550-16-7
1-benzyl-4-(1-hydroxymethylcyclohexyl)piperazine

: 1026858-98-9
methanesulfonic acid 1-(4-benzyl-piperazin-1-yl)-cyclohexylmethyl ester

Guidance literature:: With TEA; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm0311285

Reference yield:

: 55-51-6
N,N-bis(2-chloro-ethyl)-benzenemethanamine

: 1026858-98-9
methanesulfonic acid 1-(4-benzyl-piperazin-1-yl)-cyclohexylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 25 percent / NaHCO₃ / ethanol / 5 h / Heating

2: TEA / CH₂Cl₂ / 2 h / 20 °C

With TEA; sodium hydrogencarbonate; In ethanol; dichloromethane;
DOI:10.1021/jm0311285

Reference yield:

: 2756-85-6
1-aminocyclohexane carboxylic acid

: 1026858-98-9
methanesulfonic acid 1-(4-benzyl-piperazin-1-yl)-cyclohexylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: LiAlH₄ / tetrahydrofuran / 28 h / 70 - 80 °C

1.2: 68 percent / TEA / methanol / 4 h / 20 °C

2.1: 80 percent / HCl / dioxane / 1 h / 20 °C

3.1: 25 percent / NaHCO₃ / ethanol / 5 h / Heating

4.1: TEA / CH₂Cl₂ / 2 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; TEA; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1021/jm0311285