2-Propanol, 2-[(diphenylphosphino)methyl]-1,1,1,3,3,3-hexafluoro-

Base Information

Chemical Name:2-Propanol, 2-[(diphenylphosphino)methyl]-1,1,1,3,3,3-hexafluoro-
CAS No.:98331-76-1
Molecular Formula:C16H13F6OP
Molecular Weight:366.243
Hs Code.:
DSSTox Substance ID:DTXSID60464588
Nikkaji Number:J2.145.704C
Wikidata:Q82289974

Synonyms:2-Propanol, 2-[(diphenylphosphino)methyl]-1,1,1,3,3,3-hexafluoro-;98331-76-1;SCHEMBL881145;DTXSID60464588;GORJRRDZPJZJNO-UHFFFAOYSA-N;2-Propanol, 2-[(diphenylphosphino)methyl]-1,1,1,3,3,3-hexafluoro-?[

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Propanol, 2-[(diphenylphosphino)methyl]-1,1,1,3,3,3-hexafluoro-

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:366.06082100
Heavy Atom Count:24
Complexity:364

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)P(CC(C(F)(F)F)(C(F)(F)F)O)C2=CC=CC=C2

Technology Process of 2-Propanol, 2-[(diphenylphosphino)methyl]-1,1,1,3,3,3-hexafluoro-

There total 2 articles about 2-Propanol, 2-[(diphenylphosphino)methyl]-1,1,1,3,3,3-hexafluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1079-66-9,74391-44-9
chloro-diphenylphosphine

: 503169-76-4
1,1-bis(trifluoromethyl)-2-bromoethanol

: 98331-76-1
2-[(diphenylphosphanyl)methyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol

Guidance literature:: 1,1-bis(trifluoromethyl)-2-bromoethanol; With n-butyllithium; In diethyl ether; hexane; at -78 ℃;

chloro-diphenylphosphine; In diethyl ether; hexane; at -78 - 20 ℃;
DOI:10.1016/S0022-1139(02)00154-9

Reference yield: 41.0%

: 31898-68-7
2,2-bis(trifluoromethyl)oxirane

: 829-85-6
diphenylphosphane

: 98331-76-1
2-[(diphenylphosphanyl)methyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol

Guidance literature:: In tetrahydrofuran; at 25 ℃; for 48h;
DOI:10.1016/S0022-1139(02)00154-9

Reference yield: 81.0%

: 1295-35-8
bis(1,5-cyclooctadiene)nickel ⁽⁰⁾

: 98331-76-1
2-[(diphenylphosphanyl)methyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol

: 2622-14-2
tricyclohexylphosphine

: 121288-89-9
Ni⁽²⁺⁾*H^(1-)*2(P(C₆H₁₁)3)*(OC(CF₃)2CH₂P(C₆H₅)2)^(1-)

Guidance literature:: In toluene; byproducts: C8H12; (Ar); to Ni complex in toluene was added dropwise the propanol derivative with stirring at 20°C, held for 1 h, then was added excess of the phosphine; solvent filtered off, residue recrystd. from toluene/petrolether (1/10) at -20°C;