2-Butanone, 4-hydroxy-4-(6-methoxy-2-naphthalenyl)-

Base Information

Chemical Name:2-Butanone, 4-hydroxy-4-(6-methoxy-2-naphthalenyl)-
CAS No.:98386-83-5
Molecular Formula:C₁₅H₁₆O₃
Molecular Weight:244.29
Hs Code.:
DSSTox Substance ID:DTXSID20431216
Nikkaji Number:J1.065.947G

Synonyms:98386-83-5;2-Butanone, 4-hydroxy-4-(6-methoxy-2-naphthalenyl)-;4-hydroxy-4-(6-methoxynaphthalen-2-yl)butan-2-one;Methodol;4-hydroxy-4-(6-methoxy-2-naphthyl)-2-butanone;SCHEMBL60543;4-hydroxy-4-(2-methoxynaphthalen-6-yl)butan-2-one;DTXSID20431216;AS-77960;D93256

Suppliers and Price of 2-Butanone, 4-hydroxy-4-(6-methoxy-2-naphthalenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Hydroxy-nabumetone
10mg
$ 130.00

Total 4 raw suppliers

Chemical Property of 2-Butanone, 4-hydroxy-4-(6-methoxy-2-naphthalenyl)-

Chemical Property:

PSA：46.53000
LogP:2.86090
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:244.109944368
Heavy Atom Count:18
Complexity:290

Purity/Quality:

99% ^*data from raw suppliers

4-Hydroxy-nabumetone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)CC(C1=CC2=C(C=C1)C=C(C=C2)OC)O
Uses 4-Hydroxy-nabumetone is derived from 6-Methoxy-2-naphthalenecarboxaldehyde (M264760), which is used as a diagnostic reagent in tumor studies involving aldehyde dehydrogenase enzymes. In addition it is used in organic synthesis reactions forming fluorescent substrates for inhibition studies relating to hypertension and vascular inflammation.2-Butanone, 4-hydroxy-4-(6-methoxy-2-naphthalenyl)- is suitable for aldehyde dehydrogenase (ALDH) related research.

Technology Process of 2-Butanone, 4-hydroxy-4-(6-methoxy-2-naphthalenyl)-

There total 7 articles about 2-Butanone, 4-hydroxy-4-(6-methoxy-2-naphthalenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1-(6-methoxynaphthalen-2-yl)but-3-en-1-ol

: 220786-56-1,98386-83-5
(±)-4-hydroxy-4-(6-methoxy-2-naphthyl)-2-butanone

Guidance literature:: With manganese(IV) oxide; palladium dichloride; In water; acetonitrile; at 60 ℃; for 21h;
DOI:10.1039/d0ob01344g

Reference yield: 74.0%

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 67-64-1
acetone

: 220786-56-1,98386-83-5
(±)-4-hydroxy-4-(6-methoxy-2-naphthyl)-2-butanone

Guidance literature:: acetone; With lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; pH=7.5; Inert atmosphere;

6-methoxynaphthalene-2-carbaldehyde; In tetrahydrofuran; hexane; for 0.25h; Inert atmosphere;
DOI:10.1039/c3ob41898g