Benzeneethanamine, N-butyl-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-methoxy-a-methyl-2-(phenyl ethynyl)-

Base Information

• Chemical Name: Benzeneethanamine, N-butyl-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-methoxy-a-methyl-2-(phenyl ethynyl)-
• CAS No.: 99256-11-8
• Molecular Formula: C32H39NO3
• Molecular Weight: 485.667
• Mol file: 99256-11-8.mol

Synonyms:

Chemical Property of Benzeneethanamine, N-butyl-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-methoxy-a-methyl-2-(phenyl ethynyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneethanamine, N-butyl-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-methoxy-a-methyl-2-(phenyl ethynyl)-

There total 5 articles about Benzeneethanamine, N-butyl-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-methoxy-a-methyl-2-(phenyl ethynyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

butyraldehyde (123-72-8) + [2-(3,4-Dimethoxy-phenyl)-ethyl]-[2-(5-methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-amine (99255-02-4) → Butyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-[2-(5-methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-amine (99256-11-8)

Guidance literature:

With sodium cyanoborohydride; In methanol;

DOI:10.1021/jm00398a023

Reference yield:

copper(I) phenylacetylenide (13146-23-1) → Butyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-[2-(5-methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-amine (99256-11-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 18 h / Heating

2: 43 percent / NaBH₃CN / methanol

With pyridine; sodium cyanoborohydride; In methanol;

DOI:10.1021/jm00398a023

Reference yield:

1-(3-methoxyphenyl)propan-2-one (3027-13-2) → Butyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-[2-(5-methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-amine (99256-11-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 61 percent / iodine, silver acetate / acetic acid / 3 h

2: p-toluenesulfonic acid / toluene / Heating

3: pyridine / 18 h / Heating

4: 43 percent / NaBH₃CN / methanol

With pyridine; iodine; silver(I) acetate; sodium cyanoborohydride; toluene-4-sulfonic acid; In methanol; acetic acid; toluene;

DOI:10.1021/jm00398a023

upstream raw materials:

butyraldehyde

[2-(3,4-Dimethoxy-phenyl)-ethyl]-[2-(5-methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-amine

copper(I) phenylacetylenide

1-(3-methoxyphenyl)propan-2-one