Methyl 3-(p-tolyl)oxirane-2-carboxylate

Base Information

Chemical Name:Methyl 3-(p-tolyl)oxirane-2-carboxylate
CAS No.:99334-18-6
Molecular Formula:C11H12O3
Molecular Weight:192.214
Hs Code.:
European Community (EC) Number:924-646-6,686-302-9
DSSTox Substance ID:DTXSID901248705
Nikkaji Number:J184.036C

Synonyms:methyl 3-(p-tolyl)oxirane-2-carboxylate;99334-18-6;Methyl 3-(4-Methylphenyl)oxirane-2-carboxylate;SCHEMBL7906590;NRVPICMUQWVTEE-UHFFFAOYSA-N;DTXSID901248705;Methyl 3-(4-methylphenyl)-2-oxiranecarboxylate

Suppliers and Price of Methyl 3-(p-tolyl)oxirane-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Methyl 3-(p-tolyl)oxirane-2-carboxylate

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:192.078644241
Heavy Atom Count:14
Complexity:219

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2C(O2)C(=O)OC

Technology Process of Methyl 3-(p-tolyl)oxirane-2-carboxylate

There total 6 articles about Methyl 3-(p-tolyl)oxirane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 104-87-0
4-methyl-benzaldehyde

: 96-34-4
methyl chloroacetate

: 99334-18-6
(2S,3R)-3-(4-methylphenyl)-2,3-epoxypropionic acid methyl ester

Guidance literature:: methyl chloroacetate; With sodium methylate; In methanol; for 0.0833333h; Cooling with ice;

4-methyl-benzaldehyde; In methanol; at 0 ℃;
DOI:10.3390/molecules19068067

Reference yield:

: 104-87-0
4-methyl-benzaldehyde

: 96-34-4
methyl chloroacetate

: 100493-13-8
methyl 3-(p-tolyl)oxirane-2-carboxylate

: 94098-12-1,99334-18-6,100493-13-8,117083-54-2,132633-82-0
methyl cis-3-(4-tolyl)glycidate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; Overall yield = 97 percent; Overall yield = 13.05 g;
DOI:10.1016/j.tet.2020.131478

Reference yield:

: 104-87-0
4-methyl-benzaldehyde

: 94098-12-1,99334-18-6,100493-13-8,117083-54-2,132633-82-0
methyl cis-3-(4-tolyl)glycidate

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / 50percent NaOH / benzyltriethylammonium chloride / benzene; H₂O / 1 h / 5 - 10 °C

2: 1) K₂CO₃; 2) HCl/H₂O / 1) 20 deg C, 3 h; 2) 0 to 5 deg C, 2 h

With hydrogenchloride; sodium hydroxide; water; potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride; In water; benzene;