5-(4-Methoxyphenyl)-1,3,4-oxadiazole-2-carbohydrazide

Base Information

Chemical Name:5-(4-Methoxyphenyl)-1,3,4-oxadiazole-2-carbohydrazide
CAS No.:99367-60-9
Molecular Formula:C10H10N4O3
Molecular Weight:234.214
Hs Code.:
DSSTox Substance ID:DTXSID10539811
Wikidata:Q82415615

Synonyms:99367-60-9;5-(4-Methoxyphenyl)-1,3,4-oxadiazole-2-carbohydrazide;DTXSID10539811

Suppliers and Price of 5-(4-Methoxyphenyl)-1,3,4-oxadiazole-2-carbohydrazide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 5-(4-Methoxyphenyl)-1,3,4-oxadiazole-2-carbohydrazide

Chemical Property:

XLogP3:0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:234.07529019
Heavy Atom Count:17
Complexity:268

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=NN=C(O2)C(=O)NN

Technology Process of 5-(4-Methoxyphenyl)-1,3,4-oxadiazole-2-carbohydrazide

There total 3 articles about 5-(4-Methoxyphenyl)-1,3,4-oxadiazole-2-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 99367-44-9
ethyl 5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-carboxylate

: 99367-60-9
5-(4-Methoxy-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid hydrazide

Guidance literature:: With hydrazine hydrate; In methanol; diethyl ether; Ambient temperature;

Reference yield:

: 100-07-2
4-methoxy-benzoyl chloride

: 99367-60-9
5-(4-Methoxy-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid hydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / NaHCO₃ / dioxane / 10 h / 45 - 50 °C

2: 91 percent / POCl₃ / 5 h / 65 °C

3: 93 percent / NH₂NH₂*H₂O / methanol; diethyl ether / Ambient temperature

With sodium hydrogencarbonate; hydrazine hydrate; trichlorophosphate; In 1,4-dioxane; methanol; diethyl ether;

Reference yield:

: 57844-36-7
ethyl 2-(2-(4-methoxybenzoyl)hydrazinyl)-2-oxoacetate

: 99367-60-9
5-(4-Methoxy-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / POCl₃ / 5 h / 65 °C

2: 93 percent / NH₂NH₂*H₂O / methanol; diethyl ether / Ambient temperature

With hydrazine hydrate; trichlorophosphate; In methanol; diethyl ether;