methyl 5-methoxyH-pyrazolo[1,5-a]pyridine-3-carboxylate

Base Information

• Chemical Name: methyl 5-methoxyH-pyrazolo[1,5-a]pyridine-3-carboxylate
• CAS No.: 99446-31-8
• Molecular Formula: C10H10N2O3
• Molecular Weight: 206.19800
• Mol file: 99446-31-8.mol

Synonyms:methyl 5-methoxyH-pyrazolo[1,5-a]pyridine-3-carboxylate;methyl 5-methoxypyrazolo[1,5-a]pyridine-3-carboxylate;5-methoxypyrazolo[1,5-a]pyridin-3-carboxylic acid methyl ester;

Chemical Property of methyl 5-methoxyH-pyrazolo[1,5-a]pyridine-3-carboxylate

Chemical Property:

• PSA: 52.83000
• LogP: 1.12950

Purity/Quality:

98% ^*data from raw suppliers

Methyl5-methoxypyrazolo[1,5-a]pyridine-3-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 5-methoxyH-pyrazolo[1,5-a]pyridine-3-carboxylate

There total 4 articles about methyl 5-methoxyH-pyrazolo[1,5-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

N-amino-4-methoxypyridin-1-ium 2,4-dinitrophenolate + propynoic acid methyl ester (922-67-8) → 5-methoxy-pyrazolo[1,5-a]pyridine-3-carboxylic acid methyl ester (99446-31-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 31.0%

1-amino-4-methoxypyridinium iodide (143281-49-6) + propynoic acid methyl ester (922-67-8) → 5-methoxy-pyrazolo[1,5-a]pyridine-3-carboxylic acid methyl ester (99446-31-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

4-methoxypyridine (620-08-6,1232006-56-2) → 5-methoxy-pyrazolo[1,5-a]pyridine-3-carboxylic acid methyl ester (99446-31-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / acetonitrile / 24 h / 40 °C

2: 43 percent / K₂CO₃; air / dimethylformamide / 24 h / 20 °C

With air; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmc.2005.10.042

upstream raw materials:

propynoic acid methyl ester

4-methoxypyridine

1-amino-4-methoxypyridin-1-ium 2,4,6-trimethylbenzenesulfonate

1-amino-4-methoxypyridinium iodide

Downstream raw materials:

5-methoxypyrazolo[1,5-a]pyridine

pyrazolo<1,5-a>pyridin-5-ol

5-methoxypyrazolo[1,5-a]pyridine-3-carboxylic acid

pyrazolo [1,5-a]pyridine-5-carboxylic acid

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