6-Bromo-2-chloroquinoline-3-carbonitrile

Base Information

Chemical Name:6-Bromo-2-chloroquinoline-3-carbonitrile
CAS No.:99465-04-0
Molecular Formula:C10H4BrClN2
Molecular Weight:267.512
Hs Code.:2933499090
DSSTox Substance ID:DTXSID60588990
Wikidata:Q82482049
Mol file:99465-04-0.mol

Synonyms:99465-04-0;6-Bromo-2-chloroquinoline-3-carbonitrile;6-Bromo-2-chloro-3-quinolinecarbonitrile;6-BROMOQUINOLINE-2-CHLORO-3-CARBONITRILE;SCHEMBL7264580;DTXSID60588990;FFAIUVQNAJQHTR-UHFFFAOYSA-N;ZDA46504;2-chloro-6-bromo-3-cyano-quinoline;6-bromo-2-chloro-3-cyano-quinoline;MFCD09787668;AKOS005072396;AB51943;ED-0757;EN300-7543223;J-518324

Suppliers and Price of 6-Bromo-2-chloroquinoline-3-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
6-Bromo-2-chloroquinoline-3-carbonitrile
1 g
$ 344.00

SynQuest Laboratories
6-Bromo-2-chloroquinoline-3-carbonitrile
500 mg
$ 264.00

Matrix Scientific
6-Bromo-2-chloro-3-quinolinecarbonitrile >95%
500mg
$ 362.00

Matrix Scientific
6-Bromo-2-chloro-3-quinolinecarbonitrile >95%
1g
$ 454.00

Crysdot
6-Bromo-2-chloroquinoline-3-carbonitrile 97%
1g
$ 381.00

Chemenu
6-Bromo-2-chloroquinoline-3-carbonitrile 97%
1g
$ 360.00

American Custom Chemicals Corporation
6-BROMO-2-CHLORO-3-QUINOLINECARBONITRILE 95.00%
5MG
$ 504.85

AK Scientific
6-Bromo-2-chloro-3-quinolinecarbonitrile
250mg
$ 231.00

Total 12 raw suppliers

Chemical Property of 6-Bromo-2-chloroquinoline-3-carbonitrile

Chemical Property:

Vapor Pressure:4.74E-07mmHg at 25°C
Melting Point:225-227oC
Boiling Point:413.6oC at 760 mmHg
Flash Point:203.9oC
PSA：36.68000
Density:1.76g/cm3
LogP:3.52238
XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:265.92464
Heavy Atom Count:14
Complexity:262

Purity/Quality:

98%min ^*data from raw suppliers

6-Bromo-2-chloroquinoline-3-carbonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 41-25
Safety Statements: 26-39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=NC(=C(C=C2C=C1Br)C#N)Cl

Technology Process of 6-Bromo-2-chloroquinoline-3-carbonitrile

There total 4 articles about 6-Bromo-2-chloroquinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 99465-03-9
6-bromo-3-cyano-2(1H)-quinoline

: 99465-04-0
6-bromo-2-chloro-3-cyanoquinoline

Guidance literature:: With trichlorophosphate; for 1.5h; Heating;
DOI:10.1021/jm00118a034

Reference yield:

: 73568-35-1
6-bromo-2-chloro-3-formylquinoline

: 99465-04-0
6-bromo-2-chloro-3-cyanoquinoline

Guidance literature:: With ammonia; iodine; In tetrahydrofuran; water;
DOI:10.1016/j.tet.2011.09.032

Reference yield:

: 36926-82-6
2-oxo-1,2-dihydroquinoline-3-carbonitrile

: 99465-04-0
6-bromo-2-chloro-3-cyanoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / Br₂ / acetic acid / 4 h / Heating

2: 52 percent / POCl₃ / 1.5 h / Heating

With bromine; trichlorophosphate; In acetic acid;
DOI:10.1021/jm00118a034