Fatostatin

Base Information

Chemical Name:Fatostatin
CAS No.:125256-00-0
Molecular Formula:C18H18N2S
Molecular Weight:294.42
Hs Code.:2934100090
European Community (EC) Number:682-929-7
Nikkaji Number:J2.677.322I
Wikidata:Q27166821
ChEMBL ID:CHEMBL1621019
Mol file:125256-00-0.mol

Synonyms:125B11;fatostatin

Suppliers and Price of Fatostatin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
Fatostatin
10mg
$ 78.00

ChemScene
Fatostatin
25mg
$ 145.00

ChemScene
Fatostatin
100mg
$ 420.00

ChemScene
Fatostatin
50mg
$ 245.00

ChemScene
Fatostatin
5mg
$ 50.00

American Custom Chemicals Corporation
FATOSTATIN A 95.00%
5MG
$ 498.17

Ambeed
Fatostatin 98+%
1g
$ 3094.00

Ambeed
Fatostatin 98+%
50mg
$ 182.00

Ambeed
Fatostatin 98+%
25mg
$ 140.00

Ambeed
Fatostatin 98+%
10mg
$ 107.00

Total 13 raw suppliers

Chemical Property of Fatostatin

Chemical Property:

Boiling Point:474.3±55.0 °C(Predicted)
PKA:3.46±0.10(Predicted)
PSA：54.02000
Density:1.125±0.06 g/cm3(Predicted)
LogP:5.13300
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Solubility.:Soluble in DMSO (up to 25 mg/ml).
XLogP3:4.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:294.11906976
Heavy Atom Count:21
Complexity:314

Purity/Quality:

98% ^*data from raw suppliers

Fatostatin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCCC1=NC=CC(=C1)C2=NC(=CS2)C3=CC=C(C=C3)C
Description Fatostatin (125256-00-0) blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Fatostatin prevents increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice.1?Inhibits high glucose-induced TGF-β in mesangial cells.2?Cell permeable.
Uses Fatostatin A is Cell permeable inhibitor of SREBP activation.

Technology Process of Fatostatin

There total 7 articles about Fatostatin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1826-19-3
4-(4-methylphenyl)thiazole

: 98420-99-6
4-bromo-2-(n-propyl)pyridine

: 125256-00-0
2-(2-propylpyridin-4-yl)-4-p-tolylthiazole

Guidance literature:: With bis(tri-tert-butylphosphine)palladium⁽⁰⁾; lithium tert-butoxide; In 1,4-dioxane; at 100 ℃; for 48h; regioselective reaction;
DOI:10.1039/c3sc52199k

Reference yield: 28.1%

: 14222-60-7
prothionamide

: 619-41-0
4-(bromoacetyl)toluene

: 125256-00-0
2-(2-propylpyridin-4-yl)-4-p-tolylthiazole

Guidance literature:: In ethanol; at 80 ℃;
DOI:10.1021/jm500833f

Reference yield:

: C₂₃H₁₉NOS

: 125256-00-0
2-(2-propylpyridin-4-yl)-4-p-tolylthiazole

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / m-xylene / 40 h / 150 °C

2: lithium tert-butoxide; bis(tri-tert-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 48 h / 100 °C

With bis(tri-tert-butylphosphine)palladium⁽⁰⁾; caesium carbonate; lithium tert-butoxide; In 1,4-dioxane; m-xylene;
DOI:10.1039/c3sc52199k