Protionamide

Base Information

Chemical Name:Protionamide
CAS No.:14222-60-7
Molecular Formula:C9H12N2S
Molecular Weight:180.274
Hs Code.:2933399090
European Community (EC) Number:238-093-7
NSC Number:758962
UNII:76YOO33643
DSSTox Substance ID:DTXSID7045940
Nikkaji Number:J3.442H
Wikipedia:Prothionamide
Wikidata:Q866657
NCI Thesaurus Code:C72605
Metabolomics Workbench ID:153613
ChEMBL ID:CHEMBL1378024
Mol file:14222-60-7.mol

Synonyms:ektebin;Peteha;Prothionamide;Protionamide

Suppliers and Price of Protionamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Prothionamide
25g
$ 410.00

TRC
Protionamide
50g
$ 460.00

TCI Chemical
Prothionamide >98.0%(HPLC)(T)
5g
$ 29.00

TCI Chemical
Prothionamide >98.0%(HPLC)(T)
25g
$ 96.00

SynQuest Laboratories
Protionamide 98%
25 g
$ 184.00

SynQuest Laboratories
Protionamide 98%
100 g
$ 440.00

SynQuest Laboratories
Protionamide 98%
500 g
$ 1088.00

Medical Isotopes, Inc.
Protionamide
5 mg
$ 950.00

Matrix Scientific
2-Propylpyridine-4-carbothioamide
100g
$ 247.00

Matrix Scientific
2-Propylpyridine-4-carbothioamide
25g
$ 82.00

Total 97 raw suppliers

Chemical Property of Protionamide

Chemical Property:

Vapor Pressure:0.000601mmHg at 25°C
Melting Point:140-143 °C
Refractive Index:1.606
Boiling Point:310.4 °C at 760 mmHg
PKA:12.14±0.29(Predicted)
Flash Point:141.5 °C
PSA：71.00000
Density:1.136 g/cm³
LogP:2.36860
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:180.07211956
Heavy Atom Count:12
Complexity:159

Purity/Quality:

99% ^*data from raw suppliers

Prothionamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCCC1=NC=CC(=C1)C(=S)N
Recent ClinicalTrials:A Study of an Oral Short-course Regimen Including Bedaquiline for the Treatment of Participants With Multidrug-resistant Tuberculosis in China
Uses Protionamide is an antibacterial used against Mycobacterium tuberculosis bacteria. An anti-tuberculosis agent. It has also been used to treat Leprosy. Antibacterial (tuberculostatic).

Technology Process of Protionamide

There total 7 articles about Protionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.2%

: 33744-19-3
2-propylpyridine-4-carbonitrile

: 14222-60-7
prothionamide

Guidance literature:: 2-propylpyridine-4-carbonitrile; With magnesium chloride; In N,N-dimethyl-formamide; for 0.0833333h; Inert atmosphere;

With sodium hydrogen sulfide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jm500833f

Reference yield: 40.0%

: 80944-48-5
2-propylpyridine-4-carboxamide

: 14222-60-7
prothionamide

Guidance literature:: With Lawessons reagent; In tetrahydrofuran; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.ejmech.2018.09.038

Reference yield:

: 29840-73-1
2-bromopyridine-4-carboxamide

: 14222-60-7
prothionamide

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0 - 20 °C / Schlenk technique; Inert atmosphere

2: Lawessons reagent / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere

With Lawessons reagent; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1: |Negishi Coupling;
DOI:10.1016/j.ejmech.2018.09.038