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3-Azetidinecarboxylic acid, 1-[[3-fluoro-4-[5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]methyl]-

Base Information Edit
  • Chemical Name:3-Azetidinecarboxylic acid, 1-[[3-fluoro-4-[5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]methyl]-
  • CAS No.:1202073-26-4
  • Molecular Formula:C26H22FN3O2S
  • Molecular Weight:459.54
  • Hs Code.:
  • Mol file:1202073-26-4.mol
3-Azetidinecarboxylic acid, 1-[[3-fluoro-4-[5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]methyl]-

Synonyms:AMG 369;KB74649;KB-74649;KB 74649;KCMALGDZUKTGJR-UHFFFAOYSA-N;3-Azetidinecarboxylic acid, 1-[[3-fluoro-4-[5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]Methyl]-

Suppliers and Price of 3-Azetidinecarboxylic acid, 1-[[3-fluoro-4-[5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]methyl]-
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • American Custom Chemicals Corporation
  • AMG-369 95.00%
  • 5MG
  • $ 498.06
Total 6 raw suppliers
Chemical Property of 3-Azetidinecarboxylic acid, 1-[[3-fluoro-4-[5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]methyl]- Edit
Chemical Property:
  • PSA:94.56000 
  • LogP:5.03160 
Purity/Quality:

99% *data from raw suppliers

AMG-369 95.00% *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
Technology Process of 3-Azetidinecarboxylic acid, 1-[[3-fluoro-4-[5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]methyl]-

There total 7 articles about 3-Azetidinecarboxylic acid, 1-[[3-fluoro-4-[5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
2317157; With water; sodium hydroxide; In isopropyl alcohol; at 55 ℃; Large scale reaction;
With hydrogenchloride; In water; isopropyl alcohol; at 55 ℃; pH=5; Large scale reaction;
DOI:10.1021/op200192n
Guidance literature:
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran / -78 °C
1.2: -78 °C
2.1: sodium carbonate / N,N-dimethyl-formamide / 90 °C
3.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium carbonate / 1,4-dioxane; water / 80 °C
4.1: potassium tert-butylate; trimethylsulfoxonium iodide / tetrahydrofuran; dimethyl sulfoxide
5.1: sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine / methanol; dichloromethane
6.1: sodium hydroxide / tetrahydrofuran
6.2: aq. phosphate buffer
With n-butyllithium; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium tert-butylate; trimethylsulfoxonium iodide; sodium cyanoborohydride; sodium carbonate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 3.1: Suzuki reaction / 4.1: Corey-Chaykovsky reaction;
DOI:10.1021/ml100306h
Guidance literature:
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran / -78 °C
1.2: -78 °C
2.1: sodium carbonate / N,N-dimethyl-formamide / 90 °C
3.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium carbonate / 1,4-dioxane; water / 80 °C
4.1: potassium tert-butylate; trimethylsulfoxonium iodide / tetrahydrofuran; dimethyl sulfoxide
5.1: sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine / methanol; dichloromethane
6.1: sodium hydroxide / tetrahydrofuran
6.2: aq. phosphate buffer
With n-butyllithium; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium tert-butylate; trimethylsulfoxonium iodide; sodium cyanoborohydride; sodium carbonate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 3.1: Suzuki reaction / 4.1: Corey-Chaykovsky reaction;
DOI:10.1021/ml100306h
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