Benzonitrile, 2-[[2-[(3R)-3-amino-1-piperidinyl]-4-oxo-3(4H)-quinazolinyl]methyl]-

Base Information

Chemical Name:Benzonitrile, 2-[[2-[(3R)-3-amino-1-piperidinyl]-4-oxo-3(4H)-quinazolinyl]methyl]-
CAS No.:940907-93-7
Molecular Formula:C₂₁H₂₁N₅O
Molecular Weight:359.431
Hs Code.:
Mol file:940907-93-7.mol

Synonyms:2-[[2-[(3R)-3-aminopiperidin-1-yl]-4-oxoquinazolin-3-yl]methyl]benzonitrile;Benzonitrile, 2-[[2-[(3R)-3-aMino-1-piperidinyl]-4-oxo-3(4H)-quinazolinyl]Methyl]-

Suppliers and Price of Benzonitrile, 2-[[2-[(3R)-3-amino-1-piperidinyl]-4-oxo-3(4H)-quinazolinyl]methyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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American Custom Chemicals Corporation
2-[[2-[(3R)-3-AMINO-1-PIPERIDINYL]-4-OXO-3(4H)-QUINAZOLINYL]METHYL]BENZONITRILE 95.00%
5MG
$ 495.58

Total 1 raw suppliers

Chemical Property of Benzonitrile, 2-[[2-[(3R)-3-amino-1-piperidinyl]-4-oxo-3(4H)-quinazolinyl]methyl]-

Chemical Property:

PSA：87.94000
LogP:3.00928

Purity/Quality:: 2-[[2-[(3R)-3-AMINO-1-PIPERIDINYL]-4-OXO-3(4H)-QUINAZOLINYL]METHYL]BENZONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzonitrile, 2-[[2-[(3R)-3-amino-1-piperidinyl]-4-oxo-3(4H)-quinazolinyl]methyl]-

There total 3 articles about Benzonitrile, 2-[[2-[(3R)-3-amino-1-piperidinyl]-4-oxo-3(4H)-quinazolinyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 607-69-2
2-chloro-4(3H)-quinazolinone

: 127294-75-1,138060-07-8,150395-91-8,334618-23-4
3-amino-piperidine dihydrochloride

: 22115-41-9
2-(bromomethyl)benzonitrile

: 940907-93-7
2-((2-(3-aminopiperidin-1-yl)-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile

Guidance literature:: 2-chloro-4(3H)-quinazolinone; 2-(bromomethyl)benzonitrile; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

3-amino-piperidine dihydrochloride; With sodium hydrogencarbonate; In ethanol; at 150 ℃; for 6h; Further stages.;
DOI:10.1021/jm070104l

Reference yield:

: 607-68-1
2,4-dichloroquinazoline

: 940907-93-7
2-((2-(3-aminopiperidin-1-yl)-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / aq. NaOH / tetrahydrofuran / 4 h / 20 °C

2.1: K₂CO₃ / dimethylformamide / 20 °C

2.2: 108 mg / NaHCO₃ / ethanol / 6 h / 150 °C

With sodium hydroxide; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm070104l

Reference yield:

: 86-96-4
1,2,3,4-tetrahydro-quinazoline-2,4-dione

: 940907-93-7
2-((2-(3-aminopiperidin-1-yl)-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: POCl₃; N,N-dimethylaniline / 16 h / Heating

2.1: 90 percent / aq. NaOH / tetrahydrofuran / 4 h / 20 °C

3.1: K₂CO₃ / dimethylformamide / 20 °C

3.2: 108 mg / NaHCO₃ / ethanol / 6 h / 150 °C

With sodium hydroxide; potassium carbonate; N,N-dimethyl-aniline; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm070104l