Sofosbuvir

Base Information

Chemical Name:Sofosbuvir
CAS No.:1064684-44-1
Molecular Formula:C22H29FN3O9P
Molecular Weight:529.459
Hs Code.:
Mol file:1064684-44-1.mol

Synonyms:PSI 7977; L-Alanine, N-[[p(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-p-phenyl-5'-uridylyl]-, 1-methylethyl ester; Psi-7977; (S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate; sofosvuvir form6; sovaldi API; sofosbuvir form6; GS-7977; Sopropyl-(2S)-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl]-4-fluoro-3-hydroxy-4-methy-ltetrahydrofuran-2-yl]methoxy-phenoxy-phosphoryl]amino]propanoate; Sofasbuvir

Suppliers and Price of Sofosbuvir

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 15 raw suppliers

Chemical Property of Sofosbuvir

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Sofosbuvir

There total 43 articles about Sofosbuvir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.4%

: 863329-66-2,2041584-99-8
2'-deoxy-2'-fluoro-2'-methyluridine

: C₁₇H₂₀ClN₂O₅P

: 1064684-44-1,1496552-16-9
sofosbuvir

Guidance literature:: With N-ethyl-N,N-diisopropylamine; zinc(II) chloride; In tetrahydrofuran; at 55 - 60 ℃; Inert atmosphere;

Reference yield: 90.5%

: 863329-66-2,2041584-99-8
2'-deoxy-2'-fluoro-2'-methyluridine

: 1256490-52-4,1627824-09-2
(S)-2-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino]propionic acid isopropyl ester

: 1064684-44-1,1496552-16-9
sofosbuvir

Guidance literature:: 2'-deoxy-2'-fluoro-2'-methyluridine; With tert-butylmagnesium chloride; lithium chloride; In tetrahydrofuran; at 0 - 5 ℃; for 1h; Inert atmosphere;

(S)-2-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino]propionic acid isopropyl ester; In tetrahydrofuran; at -10 - -5 ℃; for 24h;

Reference yield: 89.0%

: (2S)-isopropyl 2-{[({(2R,3R,4R,5R)-3-(benzyloxy)-5-[2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-4-fluoro-4-methyltetrahydrofuran-2-yl}methoxy)(phenoxy)phosphoryl]amino}propanoate

: 1064684-44-1,1496552-16-9
sofosbuvir

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h; under 760.051 Torr;
DOI:10.1002/ejoc.201800158