Pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, N-ethyl-4-[[5-[(methoxyamino)carbonyl]-2-methylphenyl]amino]-5-methyl-

Base Information

Chemical Name:Pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, N-ethyl-4-[[5-[(methoxyamino)carbonyl]-2-methylphenyl]amino]-5-methyl-
CAS No.:427878-02-2
Molecular Formula:C19H22N6O3
Molecular Weight:382.422
Hs Code.:
Mol file:427878-02-2.mol

Synonyms:N-ethyl-3-pyrrolidinmethaneamine;3-ethylaminomethyl-pyrrolidine;N-ethyl-3-pyrrolidinemethanamine;3-Pyrrolidinemethanamine,N-ethyl;ethylpyrrolidin-3-ylmethylamine;

Suppliers and Price of Pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, N-ethyl-4-[[5-[(methoxyamino)carbonyl]-2-methylphenyl]amino]-5-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, N-ethyl-4-[[5-[(methoxyamino)carbonyl]-2-methylphenyl]amino]-5-methyl-

Chemical Property:

PKA:12.17±0.46(Predicted)
PSA：119.86000
Density:1.34±0.1 g/cm3(Predicted)
LogP:2.70210

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, N-ethyl-4-[[5-[(methoxyamino)carbonyl]-2-methylphenyl]amino]-5-methyl-

There total 7 articles about Pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, N-ethyl-4-[[5-[(methoxyamino)carbonyl]-2-methylphenyl]amino]-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1005196-62-2
4-((5-(methoxycarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid

: 427878-02-2
N-ethyl 4-((5-(methoxycarbamoyl)-2-methylphenyl)-amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide

Guidance literature:: 4-((5-(methoxycarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 - 25 ℃; for 3h;

With N-ethyl-N,N-diisopropylamine; In water; at 30 - 35 ℃; for 2h;
DOI:10.1021/op300181r

Reference yield: 77.0%

: 1005196-62-2
4-((5-(methoxycarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid

: 557-66-4
ethanamine hydrochloride

: 427878-02-2
N-ethyl 4-((5-(methoxycarbamoyl)-2-methylphenyl)-amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide

Guidance literature:: 4-((5-(methoxycarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid; ethanamine hydrochloride; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 8h; Further stages.;
DOI:10.1021/jm7009414

Reference yield:

: 5448-16-8
3-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester

: 427878-02-2
N-ethyl 4-((5-(methoxycarbamoyl)-2-methylphenyl)-amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 20 - 37 °C / Large scale

2.1: formamide; phosphoric acid / 120 °C

3.1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 2 h / 110 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 58 °C / Large scale

5.1: sodium hydroxide / water / 6 h / 60 - 65 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 3 h / 20 - 25 °C

6.2: 2 h / 30 - 35 °C

With phosphoric acid; potassium tert-butylate; benzotriazol-1-ol; formamide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/op300181r