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557-66-4 Usage


Ethylamine hydrochloride is a white to off-white crystalline compound that serves as a versatile chemical intermediate in various organic syntheses and biological studies. It is known for its significant role in the production of resins, rubber latex, and other industrial applications.


Used in Chemical Synthesis:
Ethylamine hydrochloride is used as a raw material for organic synthesis, playing a crucial role in the production of various compounds such as diethyldiazene, dimethylolethyltriazone, ethylcyanopyrolidone disperse, and 1,3-diethylthiourea. It is also a precursor for the preparation of benzilnitrate, detergents, rayon, rocket propellant, and alkyl isocyanates, which are utilized in the manufacture of pharmaceuticals.
Used in Resin and Rubber Latex Production:
Ethylamine hydrochloride is employed in the production of resins and rubber latex, contributing to the development of these materials for various industrial applications.
Used in Oil Refining:
In the oil refining industry, ethylamine hydrochloride is used to enhance the efficiency and quality of the refining process, ensuring better product output and performance.
Used in Pharmaceutical Manufacturing:
As a precursor for alkyl isocyanates, ethylamine hydrochloride finds application in the manufacture of pharmaceuticals, playing a vital role in the development of new drugs and therapies.


Ethylamine can be synthesized by ethanol and ammonia are combined in the presence of an oxide catalyst:CH3CH2OH + NH3 → CH3CH2NH2 + H2OEthylamine could then be solvent extracted or boiled out of hoffman turned to Hydrochloride with HCl and then freebased with caustic to be distilled pure.of course an excess of caustic when freebasing would be a good idea as it would hold onto most of the water created from the basing of a hydrochloride with caustic.

Purification Methods

Crystallise the hydrochloride from absolute EtOH or MeOH/CHCl3, wash with dry ether and dry it in a vacuum. [Beilstein 4 IV 310.]


Hygroscopic. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.

Check Digit Verification of cas no

The CAS Registry Mumber 557-66-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,5 and 7 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 557-66:
84 % 10 = 4
So 557-66-4 is a valid CAS Registry Number.

557-66-4 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (L03624)  Ethylamine hydrochloride, 98%   

  • 557-66-4

  • 250g

  • 518.0CNY

  • Detail
  • Alfa Aesar

  • (L03624)  Ethylamine hydrochloride, 98%   

  • 557-66-4

  • 1000g

  • 1285.0CNY

  • Detail
  • Aldrich

  • (232831)  Ethylaminehydrochloride  98%

  • 557-66-4

  • 232831-100G

  • 468.00CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name Ethylamine Hydrochloride

1.2 Other means of identification

Product number -
Other names ethanamine,hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:557-66-4 SDS

557-66-4Relevant articles and documents


, p. 835,837 (1952)

Hydrosilylative reduction of primary amides to primary amines catalyzed by a terminal [Ni-OH] complex

Bera, Jitendra K.,Pandey, Pragati

supporting information, p. 9204 - 9207 (2021/09/20)

A terminal [Ni-OH] complex1, supported by triflamide-functionalized NHC ligands, catalyzes the hydrosilylative reduction of a range of primary amides into primary amines in good to excellent yields under base-free conditions with key functional group tolerance. Catalyst1is also effective for the reduction of a variety of tertiary and secondary amides. In contrast to literature reports, the reactivity of1towards amide reduction follows an inverse trend,i.e., 1° amide > 3° amide > 2° amide. The reaction does not follow a usual dehydration pathway.

Transition metal-free catalytic reduction of primary amides using an abnormal NHC based potassium complex: Integrating nucleophilicity with Lewis acidic activation

Bhunia, Mrinal,Sahoo, Sumeet Ranjan,Das, Arpan,Ahmed, Jasimuddin,Sreejyothi,Mandal, Swadhin K.

, p. 1848 - 1854 (2020/03/03)

An abnormal N-heterocyclic carbene (aNHC) based potassium complex was used as a transition metal-free catalyst for reduction of primary amides to corresponding primary amines under ambient conditions. Only 2 mol% loading of the catalyst exhibits a broad substrate scope including aromatic, aliphatic and heterocyclic primary amides with excellent functional group tolerance. This method was applicable for reduction of chiral amides and utilized for the synthesis of pharmaceutically valuable precursors on a gram scale. During mechanistic investigation, several intermediates were isolated and characterized through spectroscopic techniques and one of the catalytic intermediates was characterized through single-crystal XRD. A well-defined catalyst and isolable intermediate along with several stoichiometric experiments, in situ NMR experiments and the DFT study helped us to sketch the mechanistic pathway for this reduction process unravelling the dual role of the catalyst involving nucleophilic activation by aNHC along with Lewis acidic activation by K ions.

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