A 876828

Base Information

• Chemical Name: A 876828
• CAS No.: 909106-60-1
• Molecular Formula: C₃₀H₃₂N₄O₆S₂
• Molecular Weight: 608.739
• Mol file: 909106-60-1.mol

Synonyms:A-876828;A 876828;

Chemical Property of A 876828

Chemical Property:

• Boiling Point: 786.6±70.0 °C (760 mmHg)
• PSA: 170.79000
• Density: 1.41±0.1 g/cm3(20 °C , 760mmHg)
• LogP: 6.74320

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of A 876828

There total 2 articles about A 876828 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

C2HF3O2*C23H26N4O6S2 + benzaldehyde (100-52-7) → N-{3-[(4S)-4-benzylamino-1-hydroxy-4-(3-methylbutyl)-3-oxo-3,4-dihydronaphthalen-2-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide (909106-60-1)

Guidance literature:

C₂HF₃O₂*C₂₃H₂₆N₄O₆S₂; benzaldehyde; With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃;

With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 24h;

DOI:10.1021/jm801485z

Reference yield: 73.0%

N-{3-[4-amino-1-hydroxy-4-(3-methylbutyl)-3-oxo-3,4-dihydronaphthalen-2-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide (909105-54-0) + benzaldehyde (100-52-7) → N-{3-[4-(benzylamino)-1-hydroxy-4-(3-methylbutyl)-3-oxo-3,4-dihydronaphthalen-2-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide (909106-60-1)

Guidance literature:

N-{3-[4-amino-1-hydroxy-4-(3-methylbutyl)-3-oxo-3,4-dihydronaphthalen-2-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide; benzaldehyde; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h;

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/jm801485z

upstream raw materials:

N-{3-[4-amino-1-hydroxy-4-(3-methylbutyl)-3-oxo-3,4-dihydronaphthalen-2-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide

benzaldehyde

Refernces