PHT-427

Base Information

• Chemical Name: PHT-427
• CAS No.: 1191951-57-1
• Molecular Formula: C20H31N3O2S2
• Molecular Weight: 409.617
• Mol file: 1191951-57-1.mol

Synonyms:PHT-427;4-Dodecyl-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Chemical Property of PHT-427

Chemical Property:

• Melting Point: 126-127 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6))
• Boiling Point: 535.0±43.0 °C(Predicted)
• PKA: 6.03±0.40(Predicted)
• PSA: 108.57000
• Density: 1.162
• LogP: 6.95610
• Storage Temp.: +2C to +8C
• Solubility.: Chloroform, Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

PHT-427 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: PHT-427 is a dual Akt and PDPK1 inhibitor with Ki of 2.7 μM and 5.2 μM, respectively. PHT-427 is a pleckstrin homology domain inhibitor to Akt and PKB Kinase (PDPK1). It can also be used for therapeutic use and biological study of mathematical modeling and parametric analysis of nanoparticle encapsulation and controlled release of a hydrophobic kinase inhibitor PHT-427.

Technology Process of PHT-427

There total 3 articles about PHT-427 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

[1,3,4]Thiadiazol-2-ylamin (4005-51-0) + p-dodecylbenzenesulfonyl chloride (52499-14-6) → ARC-183 (1191951-57-1)

Guidance literature:

With pyridine;

DOI:10.1016/j.bmc.2011.01.049

Reference yield:

1-dodecylbenzene (123-01-3) → ARC-183 (1191951-57-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 1 h / 90 °C

2: trichlorophosphate / 20 - 170 °C

3: pyridine / 0 - 95 °C

With pyridine; sulfuric acid; trichlorophosphate;

Reference yield:

potassium 4-dodecylbenzenesulfonate (14564-74-0) → ARC-183 (1191951-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 20 - 170 °C

2: pyridine / 0 - 95 °C

With pyridine; trichlorophosphate;

upstream raw materials:

[1,3,4]Thiadiazol-2-ylamin

p-dodecylbenzenesulfonyl chloride

1-dodecylbenzene

potassium 4-dodecylbenzenesulfonate

Refernces

• 1、 -. "SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME". Page/Page column 85. . Retrieved 2009/12/02.