2-[[6-[[2-(3-Hydroxypropyl)-5-methylanilino]methyl]-2-(3-morpholin-4-ylpropylamino)benzimidazol-1-yl]methyl]-6-methylpyridin-3-ol

Base Information

Chemical Name:2-[[6-[[2-(3-Hydroxypropyl)-5-methylanilino]methyl]-2-(3-morpholin-4-ylpropylamino)benzimidazol-1-yl]methyl]-6-methylpyridin-3-ol
CAS No.:857066-90-1
Molecular Formula:C₃₂H₄₂N₆O₃
Molecular Weight:558.724
Hs Code.:
UNII:538EBT31Z1
ChEMBL ID:CHEMBL408963
DSSTox Substance ID:DTXSID10235008
Wikidata:Q27261082
Mol file:857066-90-1.mol

Synonyms:2-(6-((2-(3-hydroxypropyl)-5-methylphenylamino)methyl)-2-(3-morpholin-4-ylpropylamino)benzoimidazol-1-ylmethyl)-6-methylpyridin-3-ol;TMC 353121;TMC-353121;TMC353121

Suppliers and Price of 2-[[6-[[2-(3-Hydroxypropyl)-5-methylanilino]methyl]-2-(3-morpholin-4-ylpropylamino)benzimidazol-1-yl]methyl]-6-methylpyridin-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
TMC353121 >98%
1 g
$ 3400.00

Crysdot
TMC353121 98+%
50mg
$ 553.00

Crysdot
TMC353121 98+%
10mg
$ 182.00

Crysdot
TMC353121 98+%
5mg
$ 98.00

ChemScene
TMC353121 98.97%
50mg
$ 1020.00

ChemScene
TMC353121 98.97%
5mg
$ 180.00

ChemScene
TMC353121 98.97%
10mg
$ 336.00

Chemenu
2-((6-(((2-(3-hydroxypropyl)-5-methylphenyl)amino)methyl)-2-((3-morpholinopropyl)amino)-1H-benzo[d]imidazol-1-yl)methyl)-6-methylpyridin-3-ol 98%
50mg
$ 517.00

ApexBio Technology
TMC353121
50mg
$ 1245.00

ApexBio Technology
TMC353121
5mg
$ 219.00

Total 31 raw suppliers

Chemical Property of 2-[[6-[[2-(3-Hydroxypropyl)-5-methylanilino]methyl]-2-(3-morpholin-4-ylpropylamino)benzimidazol-1-yl]methyl]-6-methylpyridin-3-ol

Chemical Property:

Melting Point:208℃
Boiling Point:822.4±75.0 °C(Predicted)
PKA:9.21±0.10(Predicted)
PSA：110.93000
Density:1.25
LogP:3.90600
Solubility.:Soluble in DMSO
XLogP3:4.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:13
Exact Mass:558.33183922
Heavy Atom Count:41
Complexity:757

Purity/Quality:

97% ^*data from raw suppliers

TMC353121 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C=C1)CCCO)NCC2=CC3=C(C=C2)N=C(N3CC4=C(C=CC(=N4)C)O)NCCCN5CCOCC5
Recent EU Clinical Trials:A double blind, randomized, placebo-controlled study to evaluate the antiviral activity, safety and plasma pharmacokinetics of multiple intravenous doses of TMC353121 in hematopoietic stem cell transplant subjects (autologous and allogeneic) with evidence of upper respiratory tract infection (URTI) caused by the respiratory syncytial virus (RSV)

Technology Process of 2-[[6-[[2-(3-Hydroxypropyl)-5-methylanilino]methyl]-2-(3-morpholin-4-ylpropylamino)benzimidazol-1-yl]methyl]-6-methylpyridin-3-ol

There total 1 articles about 2-[[6-[[2-(3-Hydroxypropyl)-5-methylanilino]methyl]-2-(3-morpholin-4-ylpropylamino)benzimidazol-1-yl]methyl]-6-methylpyridin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%