((3R,4R)-4-aMinotetrahydro-2H-pyran-3-yl)carbaMate

Base Information

• Chemical Name: ((3R,4R)-4-aMinotetrahydro-2H-pyran-3-yl)carbaMate
• CAS No.: 1240390-36-6
• Molecular Formula: C10H20N2O3
• Molecular Weight: 216.28
• Mol file: 1240390-36-6.mol

Synonyms:((3R,4R)-4-aMinotetrahydro-2H-pyran-3-yl)carbaMate;tert-butyl ((3R,4R)-4-aMinotetrahydro-2H-pyran-3-yl)carbaMate;Carbamic acid, N-[(3R,4R)-4-aminotetrahydro-2H-pyran-3-yl]-, 1,1-dimethylethyl ester

Chemical Property of ((3R,4R)-4-aMinotetrahydro-2H-pyran-3-yl)carbaMate

Chemical Property:

• PSA: 73.58000
• LogP: 1.71850
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl((3R,4R)-4-aminotetrahydro-2H-pyran-3-yl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ((3R,4R)-4-aMinotetrahydro-2H-pyran-3-yl)carbaMate

There total 9 articles about ((3R,4R)-4-aMinotetrahydro-2H-pyran-3-yl)carbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl ((3R,4R)-4-azidotetrahydro-2H-pyran-3-yl)carbamate (1240390-35-5) → tert-butyl ((3R,4R)-4-aminotetrahydro-2H-pyran-3-yl)carbamate (1240390-36-6,1350734-62-1)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; at 20 ℃; under 775.743 Torr; Inert atmosphere;

Reference yield:

2-amino-1,5-anhydro-2,4-dideoxy-L-threo-pentitol (1240390-32-2,1309081-45-5,1350734-61-0,1638744-36-1,1638771-36-4) → tert-butyl ((3R,4R)-4-aminotetrahydro-2H-pyran-3-yl)carbamate (1240390-36-6,1350734-62-1)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / methanol / 15 h / 20 °C

2: triethylamine / dichloromethane / 2 h / 0 - 20 °C

3: sodium azide; sodium acetate / N,N-dimethyl-formamide / 6 h / 100 °C

4: hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol / 760.05 Torr

With sodium azide; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium acetate; triethylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

1,5-anhydro-2-((tert-butoxycarbonyl)amino)-2,4-dideoxy-L-threo-pentitol (1240390-33-3,1707290-11-6) → tert-butyl ((3R,4R)-4-aminotetrahydro-2H-pyran-3-yl)carbamate (1240390-36-6,1350734-62-1)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2: sodium azide; sodium acetate / N,N-dimethyl-formamide / 6 h / 100 °C

3: hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol / 760.05 Torr

With sodium azide; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium acetate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl ((3R,4R)-4-azidotetrahydro-2H-pyran-3-yl)carbamate

4-bromotetrahydro-2H-pyran

dihydropyran

3,4-epoxytetrahydropyran

Downstream raw materials:

1,1-dimethylethyl [(3R,4R)-4-({5-(aminocarbonyl)-4-[(4-methylphenyl)amino]-2-pyrimidinyl}amino)tetrahydro-2H-pyran-3-yl]carbamate

C₂₄H₂₉N₅O₄S

5-((3R,4R)-3-aminotetrahydro-2H-pyran-4-ylamino)-3-(p-tolylamino)pyrazine-2-carboxamide

5-((3R,4R)-3-aminotetrahydro-2H-pyran-4-ylamino)-3-(p-tolylamino)pyrazine-2-carbonitrile

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