3,6-Dihydro-2H-pyran

Base Information

• Chemical Name: 3,6-Dihydro-2H-pyran
• CAS No.: 3174-74-1
• Molecular Formula: C5H8 O
• Molecular Weight: 84.1179
• Hs Code.: 2932999099
• European Community (EC) Number: 822-338-5
• DSSTox Substance ID: DTXSID10953679
• Nikkaji Number: J381.385A
• Mol file: 3174-74-1.mol

Synonyms:3,6-dihydro-2H-pyran

Chemical Property of 3,6-Dihydro-2H-pyran

Chemical Property:

• Vapor Pressure: 42.5mmHg at 25°C
• Boiling Point: 100.3°Cat760mmHg
• Flash Point: °C
• PSA: 9.23000
• Density: 0.926g/cm³
• LogP: 0.96290
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 84.057514874
• Heavy Atom Count: 6
• Complexity: 57

Purity/Quality:

98%, ^*data from raw suppliers

3,6-Dihydro-2H-pyran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCC=C1
• Uses: 3,6-Dihydro-2H-pyran is a reactant used in epoxide formation reactions involved in the synthesis of pharmaceuticals.

Technology Process of 3,6-Dihydro-2H-pyran

There total 8 articles about 3,6-Dihydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + propene (187737-37-7,13987-01-4,15220-87-8,9003-07-0,676-63-1,25085-53-4) → dihydropyran (3174-74-1) + homoalylic alcohol (627-27-0) + butyraldehyde (123-72-8)

Guidance literature:

With zeolite Zn/H-beta; In 1,4-dioxane; at 119.84 ℃; for 2.5h; Catalytic behavior;

DOI:10.1002/cctc.201701315

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + propene (187737-37-7,13987-01-4,15220-87-8,9003-07-0,676-63-1,25085-53-4) → Tetrahydro-pyran-4-ol (2081-44-9) + dihydropyran (3174-74-1) + homoalylic alcohol (627-27-0) + butyraldehyde (123-72-8)

Guidance literature:

With zeolite Zn/H-beta; In 1,4-dioxane; at 119.84 ℃; for 2.5h; Reagent/catalyst; Temperature; Catalytic behavior;

DOI:10.1002/cctc.201701315

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + propene (187737-37-7,13987-01-4,15220-87-8,9003-07-0,676-63-1,25085-53-4) → 4-methyl-1,3-dioxane (1120-97-4) + Tetrahydro-pyran-4-ol (2081-44-9) + dihydropyran (3174-74-1) + homoalylic alcohol (627-27-0) + butyraldehyde (123-72-8)

Guidance literature:

With zeolite Zn/H-beta; In 1,4-dioxane; at 119.84 ℃; for 2.5h; Reagent/catalyst; Temperature; Catalytic behavior;

DOI:10.1002/cctc.201701315

upstream raw materials:

6-methoxy-3,6-dihydro-2H-pyran

isobutylmagnesium bromide

isopropylmagnesium bromide

formaldehyd

Downstream raw materials:

7-chloro-7-phenyl-3-oxabicyclo<4.1.0>heptane

Tetrahydro-3-(4-methylphenylsulfonylamino)-4-pyranol

Tetrahydro-4-(4-methylphenylsulfonylamino)-3-pyranol

(+/-)-2,6-dimethyl-6-tetrahydropyranyl(THP)oxymethyl-2-cyclohexen-1-one

Refernces

• 1、 Kang, Qi-Kai,Li, Ke,Li, Yuntong,Lin, Yunzhi,Shi, Hang,Xu, Lun. "Catalytic SNAr Hydroxylation and Alkoxylation of Aryl Fluorides". supporting information. p. 20391 - 20399. Retrieved 2021/08/13.
• 2、 Guagnano, Vito,Lardicci, Luciano,Malanga, Corrado,Menicagli, Rita. "Regioselective Ni(II)-assisted alkylation of 2-methoxy-5,6- dihydro-2H-pyran: A new route to 2-n.alkyl-5,6-dihydro-2H-pyrans". . p. 2025 - 2026. Retrieved 2007/10/03.