Perindopril Benzyl Ester

Base Information

Chemical Name:Perindopril Benzyl Ester
CAS No.:122454-52-8
Molecular Formula:C26H38N2O5
Molecular Weight:458.598
Hs Code.:
DSSTox Substance ID:DTXSID60554973
Mol file:122454-52-8.mol

Synonyms:Perindopril Benzyl Ester;122454-52-8;benzyl 1-[2-[(1-ethoxy-1-oxopentan-2-yl)amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylate;1-[2-[(1-ethoxy-1-oxopentan-2-yl)amino]-1-oxopropyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid (phenylmethyl) ester;DTXSID60554973;A804898;J-004804;benzyl 1-[2-(1-ethoxycarbonylbutylamino)propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylate;Benzyl 1-{2-[(1-ethoxy-1-oxopentan-2-yl)amino]propanoyl}octahydro-1H-indole-2-carboxylate (non-preferred name)

Suppliers and Price of Perindopril Benzyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
PerindoprilBenzylEster
1 g
$ 1230.00

Medical Isotopes, Inc.
PerindoprilBenzylEster
1 g
$ 2120.00

American Custom Chemicals Corporation
PERINDOPRIL BENZYL SALICYLATE 95.00%
1G
$ 1871.10

American Custom Chemicals Corporation
PERINDOPRIL BENZYL SALICYLATE 95.00%
100MG
$ 739.20

Total 14 raw suppliers

Chemical Property of Perindopril Benzyl Ester

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.53
Boiling Point:582.399°C at 760 mmHg
Flash Point:306.024°C
PSA：84.94000
Density:1.128g/cm³
LogP:3.92820
Solubility.:Dichloromethane, Ether, Ethyl Acetate, Methanol
XLogP3:5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:12
Exact Mass:458.27807232
Heavy Atom Count:33
Complexity:663

Purity/Quality:

97% ^*data from raw suppliers

PerindoprilBenzylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)OCC3=CC=CC=C3
Uses Perindopril (P287500) derivative.

Technology Process of Perindopril Benzyl Ester

There total 11 articles about Perindopril Benzyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 94062-52-9,82717-91-7
(2S,3aS,7aS)-octahydro-1H-indole-2-carboxylic acid phenylmethyl ester 4-methylbenzenesulfonate

: 82834-12-6
N-<1(S)-(ethoxycarbonyl)butyl>-L-alanine

: 122454-52-8
(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 20 - 25 ℃;

Reference yield: 94.0%

: 94062-52-9,82717-91-7
(2S,3aS,7aS)-octahydro-1H-indole-2-carboxylic acid phenylmethyl ester 4-methylbenzenesulfonate

: 82834-12-6
N-<1(S)-(ethoxycarbonyl)butyl>-L-alanine

: 121-44-8
triethylamine

: 64407-57-4
N,N-dicyclohexylurea

: 122454-52-8
(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid benzyl ester

Guidance literature:: (2S,3aS,7aS)-octahydro-1H-indole-2-carboxylic acid phenylmethyl ester 4-methylbenzenesulfonate; triethylamine; In ethyl acetate; at 25 ℃;

N-<1(S)-(ethoxycarbonyl)butyl>-L-alanine; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethyl acetate; at 15 - 25 ℃; for 3h; Product distribution / selectivity;