64407-57-4

Upstream product

• 23408-05-1 2-Hydroxy-benzoic acid tert-butyl ester 
• 20972-37-6 (E)-4-(4-methoxyphenyl)-4-oxo-2-butenoic acid 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 105-36-2 ethyl bromoacetate 
• 344407-83-6 4-Phenylbutylphosphonous acid 
• 14332-09-3 hypophosphorous acid 
• 151-51-9 carbodiimide 
• 15535-98-5 p-hydroxybenzamidine 
• 94062-52-9 (2S,3aS,7aS)-octahydro-1H-indole-2-carboxylic acid phenylmethyl ester 4-methylbenzenesulfonate 
• 82834-12-6 N-<1(S)-(ethoxycarbonyl)butyl>-L-alanine 
• 121-44-8 triethylamine 
• 59178-92-6 N-methacryloyl-6-aminohexanoic acid 
• 96-53-7 2-mercaptothiazoline 
• 538-75-0 dicyclohexyl-carbodiimide 

Downstream Products

• 281660-19-3 2,4-hexadienyl-2,4-dihydroxy benzoate 
• 1541-19-1 ethyl N-cyclohexylcarbamate 
• 281660-18-2 2,4-hexadienyl-4-hydroxy benzoate 

Relevant academic research and scientific papers

Self-assembly and micellization of a dual thermoresponsive supramolecular pseudo-block copolymer

This paper reports the studies on self-assembly and thermosensitive micellization phenomena of a supramolecular polymeric host-guest system consisting of star-shaped poly(N-isopropylacrylamide) (PNIPAAm) with a β-cyclodextrin (β-CD) core (the host polymer

A dual responsive "turn-on" fluorophore for orthogonal selective sensing of biological thiols and hydrogen peroxide

Both thiols and hydrogen peroxide (H2O2) have great correlations with cancer and other diseases, and hence detection probes for sensing these agents may serve as early diagnostic tools. In this article, we report the development of a

METHOD FOR THE IMMOBILIZATION OF BIOMOLECULES

The invention relates to a method for the immobilization of biomolecules containing at least one sulfhydryl group, which method comprises contacting a modified metal surface with the biomolecule irradiating the resulting surface with UV radiation in the presence of a photo-initiator, wherein said metal surface is modified with a cross-linker compound comprising a terminal thiol or dithiol group covalently linked to the metal surface, a spacer group, which at the other terminal end is carrying an isolated double or triple bond.

BETA-SUBSTITUTED GAMMA-AMINO ACIDS AND ANALOGS AS CHEMOTHERAPEUTIC AGENTS

β-Substituted γ-amino acids, β-substituted γ-amino acid derivatives, and β-substituted γ-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The β-substituted γ-amino acid derivatives and β-substituted γ-amino acid analogs and (bio)isosteres are selective LAT1/4F2hc substrates, capable of passing through the blood-brain barrier, and exhibit rapid uptake and retention in tumors expressing the LAT1/4F2hc transporter. Methods of synthesizing the β-substituted γ-amino acid derivatives and β-substituted γ-amino acid analogs and (bio)isosteres and methods of using the compounds for treating tumors are also disclosed. The β-substituted γ-amino acid derivatives and β-substituted γ-amino acid analogs and (bio)isosteres exhibit an improved selectivity toward tumor cells expressing the LAT1/4F2hc transporter and accumulate in cancerous cells when administered to a subject in vivo. The β-substituted γ-amino acid derivatives and β-substituted γ-amino acid analogs and (bio)isosteres exhibit an increased efficacy on a variety of tumor types.

New fatty acid derivatives based on barbiturates and other cyclic β-dicarbonyl compounds and an acyl migration

The use of DCC, triethylamine and 4-dimethylaminopyridine in dichloromethane provides a general and standard one-pot procedure for the O-acylation of cyclic β-dicarbonyl compound derivatives (1) with palmitic and stearic acids which have long hydrocarbon tails, to synthesis of new type of fatty acid derivative in good to excellent yields. Structure elucidation was carried out by FT-IR, 1H NMR and 13C NMR spectroscopy techniques. The acyl migration was also found in results and the corresponding structure was characterized by X-ray crystallography. A proposed mechanism was discussed for the formation of products.

Ritalinic acid immunoassay

The invention provides novel antibodies which specifically bind to the methylphenidate metabolite ritalinic acid, enabling an immunoassay that can detect methyphenidate in biological samples for an extended period following its ingestion. The invention also describes novel conjugates and kits incorporating the antibodies.

Detection of synthetic cannabinoids

The invention describes methods and kits for detecting and determining current and future synthetic cannabinoids from the JWH and CP families. Unique antibodies derived from immunogens enable said methods and kits.

Detection of synthetic cannabinoids

The invention describes methods and kits for detecting and determining current and future synthetic cannabinoids from the JWH and RCS families. Unique antibodies derived from immunogens enable said methods and kits.

Assay for benzylpiperazines and metabolites

The invention relates to the detection and quantification of 1-benzylpiperazine and its metabolites. The invention is underpinned by novel polyclonal antibodies with unique binding properties which enable immunoassay methods and kits for various applications.

Assay for Benzylpiperazine and Metabolites

The invention relates to the detection and quantification of 1-benzylpiperazine and its metabolites. The invention is underpinned by novel polyclonal antibodies with unique binding properties which enable immunoassay methods and kits for various applications.