3-hydroxyphenylacetaldehyde

Base Information

• Chemical Name: 3-hydroxyphenylacetaldehyde
• CAS No.: 81104-39-4
• Molecular Formula: C₈H₈O₂
• Molecular Weight: 136.15
• Mol file: 81104-39-4.mol

Synonyms:

Chemical Property of 3-hydroxyphenylacetaldehyde

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-hydroxyphenylacetaldehyde

There total 7 articles about 3-hydroxyphenylacetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3-(2-methoxyethyl)phenol (32846-01-8) → 3-hydroxyphenylacetaldehyde (81104-39-4)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; for 6h; Reflux;

DOI:10.1021/jm8002153

Reference yield: 22.0%

2-(3-hydroxyphenyl)ethanol (13398-94-2) → 3-hydroxyphenylacetaldehyde (81104-39-4)

Guidance literature:

With sulfur trioxide pyridine complex; triethylamine; In dimethyl sulfoxide; at 20 ℃; for 1h;

Reference yield:

m-tyrosine (587-33-7,775-06-4,2180-37-2,32140-49-1,29562-33-2) → 3-hydroxyphenylacetaldehyde (81104-39-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tyrosine decarboxylase from Enterococcus faecalis DC₃₂; sodium L-ascorbate; copper(ll) sulfate pentahydrate; pyridoxal 5'-phosphate / dimethyl sulfoxide / 8 h / pH 5.5 / Enzymatic reaction

2: sodium pyruvate; transaminase from chromobacterium violaceum / Enzymatic reaction

With copper(ll) sulfate pentahydrate; pyridoxal 5'-phosphate; transaminase from chromobacterium violaceum; tyrosine decarboxylase from Enterococcus faecalis DC₃₂; sodium pyruvate; sodium L-ascorbate; In dimethyl sulfoxide;

DOI:10.1002/anie.201902761

upstream raw materials:

etilefrine

Phenylephrine

phosphoric acid

3-(2-methoxyethyl)phenol

Downstream raw materials:

4-(3-hydroxyphenyl)-2-aminothiazole

S-ethyl S-hexyl O-(3-formylmethylphenyl) dithiophosphate

(3-{(4R,5S)-2-Acetoxy-4-hydroxy-5-[(E)-(S)-3-hydroxy-4-(3-hydroxy-phenyl)-but-1-enyl]-cyclopent-1-enylsulfanyl}-propylsulfanyl)-acetic acid methyl ester