13398-94-2

Usage

Uses

Used in Chemical Research:
3-HYDROXYPHENETHYL ALCOHOL is used as a research compound for studying its inelastic electron tunneling (IET) spectra, which helps in understanding its molecular structure and properties.

InChI:InChI=1/C8H10O2/c9-5-4-7-2-1-3-8(10)6-7/h1-3,6,9-10H,4-5H2

Upstream product

• 5020-41-7 2-(3-methoxyphenyl)-ethanol 
• 621-37-4 m-hydroxyphenylacetic acid 
• 42058-59-3 3-hydroxy-benzeneacetic acid, methyl ester 
• 620-18-8 3-hydroxystyrene 
• 60-12-8 2-phenylethanol 

Downstream Products

• 52059-50-4 2-(3-hydroxyphenyl)ethyl bromide 
• 121442-60-2 tert-Butyl-[2-(3-methoxymethoxy-phenyl)-ethoxy]-dimethyl-silane 
• 132418-16-7 methyl 3-(2-hydroxyethyl)phenoxyacetate 
• 160701-51-9 1-(tert-Butyl-dimethyl-silanyloxy)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-benzene 
• 151287-95-5 acetic acid 2-(3-hydroxyphenyl)ethyl ester 
• 372522-93-5 2-(3-allyloxyphenyl)ethanol 
• 862805-77-4 2-[3-(2-hydroxyethyl)phenoxy]acetic acid ethyl ester 
• 372522-91-3 acetic acid 2-(3-allyloxy-4-cyanophenyl)ethyl ester 
• 372523-22-3 benzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]phenyl ester 
• 372523-15-4 benzenesulfonic acid 3-[2-(3-allyloxyphenyl)ethoxy]-5-ethylphenyl ester 
• 372523-04-1 benzenesulfonic acid 3-[2-(3-allyloxy-4-cyanophenyl)ethoxy]phenyl ester 
• 372523-23-4 2-methoxy-5-methylbenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]phenyl ester 
• 372523-26-7 toluene-3-sulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-methylphenyl ester 

Relevant academic research and scientific papers

The influence of key residues in the tunnel entrance and the active site on activity and selectivity of toluene-4-monooxygenase

Site-directed saturation mutagenesis is a convenient method to fine tune enzyme activity and selectivity at known "hot spots". The objective of this work was to investigate the influence of mutations in the tunnel entrance of toluene 4-monooxygenase (T4MO

BIFUNCTIONAL COMPOUNDS

The invention provides a bifunctional compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein said Targeting Ligand, Linker and Degron are as described herein.

1-(1-Arylethylpiperidin-4-yl)thymine analogs as antimycobacterial TMPK inhibitors

A series of Mycobacterium tuberculosis TMPK (MtbTMPK) inhibitors based on a reported compound 3 were synthesized and evaluated for their capacity to inhibit MtbTMPK catalytic activity and the growth of a virulent M. tuberculosis strain (H37Rv). Modifications of the scaffold of 3 failed to afford substantial improvements in MtbTMPK inhibitory activity and antimycobacterial activity. Optimization of the substitution pattern of the D ring of 3 resulted in compound 21j with improved MtbTMPK inhibitory potency (three-fold) and H37Rv growth inhibitory activity (two-fold). Moving the 3-chloro substituent of 21j to the para-position afforded isomer 21h, which, despite a 10-fold increase in IC50-value, displayed promising whole cell activity (minimum inhibitory concentration (MIC) = 12.5 μM).

Synthesis of high added value compounds through catalytic oxidation of 2-phenylethanol: A Kinetic study

An effective procedure was developed to produce high-value added phenolic compounds through the conversion of 2-phenylethanol (2-PhEt) by using acid-activated clays KSF for the hydrogen peroxide. Owing to KSF's ability to catalyze a variety of complex oxi

Improving process conditions of hydroxytyrosol synthesis by toluene-4-monooxygenase

Toluene-4-monooxygenase from Pseudomonas mendocina KR1 was recently engineered for the synthesis of hydroxytyrosol, a potent antioxidant. Following a 190-fold improvement in the enzyme activity by protein engineering means, improving the process conditions of this biocatalytic route was under taken for developing a liter-scale bioprocess. The growth stage was improved by selection of a rich media and harvesting the cells at the end of the logarithmic stage. The biotransformation stage was optimized by evaluating substrate concentration, cell density, and different operational modes. It was found that although reusing the cells in successive batch modes is feasible, their activity is dramatically decreased after the first use. In comparison, the activity of the cells following subsequent substrate addition in a fed batch mode was only slightly decreased. Furthermore, a better yield was obtained by extending the duration of the biotransformation stage, rather than adding more substrate. An overall concentration of 133 mg/L HTyr, corresponding to a volumetric productivity of 54 mg/L/h and a yield of 48% was achieved by a batch mode using 2 mM substrate. This is an order of magnitude improvement compared with the enzyme productivity before the process optimization. The use of beads conjugated with phenylboronic acid residues for adsorbing the product from the biotransformation bulk was evaluated. Though the recovery yield and purity were shown to be oppositely dependent, an average recovery procedure led to 2-fold purification of HTyr resulting in 84% purity with 70% recovery yield.

1,2,4-Triazine Derivatives, Preparation and Use Thereof in Human Therapy

The invention concerns 3,5-dioxo-(2H,4H)-1,2,4-triazine derivatives of general formula (I), wherein: R1 and R2, identical or different, represent a branched or linear C1-C7 alkyl or alkenyl radical, a C1/s

FURAN-2-CARBOXYLIC ACID DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF

This invention relates to a furan-2-carboxylic acid derivative capable of activating AMP-activated protein kinase (AMPK), which is useful for the prevention and treatment of metabolic syndromes including diabete, obesity, hyperlipidemia, hypercholesterole

PYRROLE DERIVATIVE

A novel pyrrole derivative represented by the following formula (1) and a salt thereof: wherein R1 means substituted alkenyl, etc.; R2 means substituted benzoyl, etc.; and R3 to R5 each means hydrogen, alkyl, halogeno, etc. The derivative and salt have antidiabetic activity.

Selective ortho-cleavage of methoxymethyl- and 4-methoxybenzyl ethers

Iodine in methanol has been found to be an effective catalyst system for the cleavage of alkoxymethyl ethers. This catalyst system is particularly useful for the selective removal of ortho-methoxymethyl- and ortho-(4-methoxybenzyl) ethers in the presence

One-pot synthesis of 6-hydroxyisochromans: The example of demethyl-oxa-coclaurine

Using a modified oxa-Pictet Spengler reaction that we recently described, we synthesized 6-hydroxy-isochromans and their 7-hydroxy derivatives. The successful one step synthesis did not require protecting groups and provided high yields. The obtainment of 1-(4′ -hydroxybenzyl)-6,7-dihydroxyisochroman (1) indicates that this protocol can be used to synthesize oxygenated analogues of benzyl-tetrahydroisoquinoline alkaloids, such as demethyl-coclaurine (2). This methodology could provide a general procedure for the synthesis of hydroxyisochromans. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.