Ethyl 8-allyl-5-hydroxy-7-oxo-2-phenyl-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate

Base Information

• Chemical Name: Ethyl 8-allyl-5-hydroxy-7-oxo-2-phenyl-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate
• CAS No.: 76360-63-9
• Molecular Formula: C₁₉H₁₇N₃O₄
• Molecular Weight: 351.362
• Hs Code.: 2933990090
• Mol file: 76360-63-9.mol

Synonyms:(6Z)-6-[ethoxy(hydroxy)methylidene]-2-phenyl-8-prop-2-enylpyrido[2,3-d]pyrimidine-5,7-dione;

Chemical Property of Ethyl 8-allyl-5-hydroxy-7-oxo-2-phenyl-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate

Chemical Property:

• Boiling Point: 467.144 °C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 236.321 °C
• PSA: 94.31000
• Density: 1.325 g/cm³
• LogP: 2.52680

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 8-allyl-5-hydroxy-7-oxo-2-phenyl-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 8-allyl-5-hydroxy-7-oxo-2-phenyl-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate

There total 2 articles about Ethyl 8-allyl-5-hydroxy-7-oxo-2-phenyl-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-propenyl)-7-phenyl-2H-pyrimido[4,5-d][1,3]-oxazine-2,4(1H)-dione (76360-66-2) + diethyl malonate (105-53-3) → 7,8-dihydro-5-hydroxy-7-oxo-2-phenyl-8-(2-propenyl)pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (76360-63-9)

Guidance literature:

With NaOEt; In N,N-dimethyl-formamide;

Reference yield:

4-(2-propenylamino)-2-phenyl-5-pyrimidine carboxylic acid ethyl ester (76360-64-0) + 2-ethylmalonyl dichloride (55552-69-7) → 7,8-dihydro-5-hydroxy-7-oxo-2-phenyl-8-(2-propenyl)pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (76360-63-9)

Guidance literature:

In diethyl ether; ethanol; water;

upstream raw materials:

1-(2-propenyl)-7-phenyl-2H-pyrimido[4,5-d][1,3]-oxazine-2,4(1H)-dione

diethyl malonate

4-(2-propenylamino)-2-phenyl-5-pyrimidine carboxylic acid ethyl ester

2-ethylmalonyl dichloride

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