6-(2-Methyl-1,3-dioxolan-2-yl)-2-pyridinecarboxylic acid

Base Information

• Chemical Name: 6-(2-Methyl-1,3-dioxolan-2-yl)-2-pyridinecarboxylic acid
• CAS No.: 122637-38-1
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.202
• Hs Code.: 2933399090
• Mol file: 122637-38-1.mol

Synonyms:methyldioxolanylpyridinecarboxylicacid;

Chemical Property of 6-(2-Methyl-1,3-dioxolan-2-yl)-2-pyridinecarboxylic acid

Chemical Property:

• PSA: 68.65000
• LogP: 0.99930
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

6-(2-Methyl-1,3-dioxolan-2-yl)-2-pyridinecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(2-Methyl-1,3-dioxolan-2-yl)-2-pyridinecarboxylic acid

There total 3 articles about 6-(2-Methyl-1,3-dioxolan-2-yl)-2-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2‐bromo‐6‐(2‐methyl‐1,3‐dioxolan‐2‐yl)pyridine (49669-14-9) + carbon dioxide (124-38-9,18923-20-1) → 6-(2’-methyl-1’,3’-dioxolan-2’-yl)-2-pyridinecarboxylic acid (122637-38-1)

Guidance literature:

2‐bromo‐6‐(2‐methyl‐1,3‐dioxolan‐2‐yl)pyridine; With n-butyllithium; In diethyl ether;

carbon dioxide;

With hydrogenchloride; In water;

DOI:10.1021/ic500638z

Reference yield:

1-(6-bromopyridin-2-yl)-ethanone (49669-13-8) → 6-(2’-methyl-1’,3’-dioxolan-2’-yl)-2-pyridinecarboxylic acid (122637-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 89 percent / 4-toluenesulfonic acid monohydrate / toluene / 24 h / Heating

2.1: n-butylithium / diethyl ether / 0.5 h / -60 °C

2.2: 57 percent / diethyl ether / -60 - 20 °C

With n-butyllithium; p-toluenesulfonic acid monohydrate; In diethyl ether; toluene;

DOI:10.1039/b618258e

Reference yield:

2,6-Dibromopyridine (626-05-1) → 6-(2’-methyl-1’,3’-dioxolan-2’-yl)-2-pyridinecarboxylic acid (122637-38-1)

Guidance literature:

Multi-step reaction with 3 steps

1: n-butyllithium

2: toluene-4-sulfonic acid

3: n-butyllithium / diethyl ether

With n-butyllithium; toluene-4-sulfonic acid; In diethyl ether;

DOI:10.1021/ic500638z

upstream raw materials:

2‐bromo‐6‐(2‐methyl‐1,3‐dioxolan‐2‐yl)pyridine

carbon dioxide

1-(6-bromopyridin-2-yl)-ethanone

2,6-Dibromopyridine

Downstream raw materials:

6-acetylpyridine-2-carboxylic acid

C₃₂H₄₀ClCuN₃O

C₂₈H₃₂ClCuN₃O

C₂₈H₃₃Cl₂CuN₃O

Refernces

• 1、 Ronson, Tanya K.,Adams, Harry,Harding, Lindsay P.,Pope, Simon J. A.,Sykes, Daniel,Faulkner, Stephen,Ward, Michael D.. "Polynuclear lanthanide complexes of a series of bridging ligands containing two tridentate N,N′,O-donor units: Structures and luminescence properties". . p. 1006 - 1022. Retrieved 2007/10/03.