8-Fluoro-6-methoxy Moxifloxacin Dihydrochloride

Base Information

• Chemical Name: 8-Fluoro-6-methoxy Moxifloxacin Dihydrochloride
• CAS No.: 1029364-77-9
• Molecular Formula: C21H24FN3O4
• Molecular Weight: 401.438
• Hs Code.: 29339900
• Mol file: 1029364-77-9.mol

Synonyms:UNII-8175L96X3L; 8-Fluoro-6-methoxy Moxifloxacin Dihydrochloride; 8-Fluoro-6-methoxymoxifloxacin; Moxifloxacin hydrochloride specified impurity D [EP]; Moxifloxacin Imp. D (EP/BP) as diHCl salt;

Chemical Property of 8-Fluoro-6-methoxy Moxifloxacin Dihydrochloride

Chemical Property:

• Melting Point: 100-104°C
• Boiling Point: 633.9±55.0 °C(Predicted)
• PKA: 6.44±0.50(Predicted)
• PSA: 83.80000
• Density: 1.408
• LogP: 2.76430
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

99%, ^*data from raw suppliers

8-Fluoro-6-methoxy moxifloxacin dihydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 8-Fluoro-6-methoxy Moxifloxacin Dihydrochloride (Moxifloaxacin EP Impurity D) is an impurity of Moxifloxacin (M745000). Moxifloxacin (M745000) impurity D.

Technology Process of 8-Fluoro-6-methoxy Moxifloxacin Dihydrochloride

There total 10 articles about 8-Fluoro-6-methoxy Moxifloxacin Dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.3%

C14H11F2NO4 + (1S,6S)-2,8-diazabicyclo[4.3.0]nonane (151213-40-0,158060-81-2,169533-56-6) → 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid (1029364-77-9)

Guidance literature:

C₁₄H₁₁F₂NO₄; With isobutylamine; copper dichloride; In methanol; ethylene glycol; at 50 ℃; for 4h; Inert atmosphere;

(1S,6S)-2,8-diazabicyclo[4.3.0]nonane; In methanol; ethylene glycol; for 5h; Reflux;

Reference yield:

C25H29BFN3O8 → 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid (1029364-77-9)

Guidance literature:

With sodium hydroxide; at 80 - 85 ℃;

Reference yield:

C8H4ClF3O2 → 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid (1029364-77-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: tetrachloromethane; magnesium / ethanol; toluene / 55 - 60 °C

1.2: 2 h / 30 - 35 °C

2.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide; water / 10 h / 100 - 110 °C

3.1: 110 - 120 °C

4.1: dichloromethane / 0 - 40 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 75 - 80 °C

6.1: zinc(II) chloride / 2 h / 110 - 115 °C

6.2: 85 - 115 °C

7.1: triethylamine / acetonitrile / 3 h / 20 - 95 °C

8.1: sodium hydroxide / 80 - 85 °C

With tetrachloromethane; potassium carbonate; toluene-4-sulfonic acid; magnesium; triethylamine; sodium hydroxide; zinc(II) chloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

upstream raw materials:

2,3,4-trifluoro-5-methoxybenzoic acid

(1S,6S)-2,8-diazabicyclo[4.3.0]nonane

Refernces

• 1、 -. "A preparation of Moxifloxacin impurity B and impurity D method". . . Retrieved 2017/03/08.