2-BROMO-4-(TRIFLUOROMETHYL)BENZENEBORONIC ACID

Base Information

• Chemical Name: 2-BROMO-4-(TRIFLUOROMETHYL)BENZENEBORONIC ACID
• CAS No.: 959997-88-7
• Molecular Formula: C7H5BBrF3O2
• Molecular Weight: 268.826
• Hs Code.: 2931900090
• Mol file: 959997-88-7.mol

Synonyms:2-BROMO-4-(TRIFLUOROMETHYL)BENZENEBORONIC ACID;4-Borono-3-bromobenzotrifluoride

Chemical Property of 2-BROMO-4-(TRIFLUOROMETHYL)BENZENEBORONIC ACID

Chemical Property:

• PSA: 40.46000
• LogP: 1.14770
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-4-(trifluoromethyl)phenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-4-(TRIFLUOROMETHYL)BENZENEBORONIC ACID

There total 1 articles about 2-BROMO-4-(TRIFLUOROMETHYL)BENZENEBORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

triethyl borate (150-46-9) + 2-bromo-1-iodo-4-(trifluoromethyl)benzene (481075-58-5) → (2-bromo-4-(trifluoromethyl)phenyl)boronic acid (959997-88-7)

Guidance literature:

2-bromo-1-iodo-4-(trifluoromethyl)benzene; With isopropylmagnesium chloride; In tetrahydrofuran; diethyl ether; at -78 ℃; for 2h;

triethyl borate; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; diethyl ether; water; at 20 ℃; for 0.5h;

DOI:10.1021/ol5006246

Reference yield: 70.0%

methyl thiotosylate (4973-66-4) + (2-bromo-4-(trifluoromethyl)phenyl)boronic acid (959997-88-7) → 2-bromo-4-(trifluoromethyl)phenyl methyl sulfide

Guidance literature:

With sodium hydrogencarbonate; copper(II) sulfate; In methanol; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1246/cl.180304

Reference yield: 69.0%

bis(4-methylphenyl) sulfone (599-66-6) + (2-bromo-4-(trifluoromethyl)phenyl)boronic acid (959997-88-7) → 2-bromo-4-(trifluoromethyl)phenyl 4-tolyl sulfide

Guidance literature:

With sodium hydrogencarbonate; copper(II) sulfate; In methanol; at 20 ℃; for 19h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b02599

upstream raw materials:

triethyl borate

2-bromo-1-iodo-4-(trifluoromethyl)benzene

Downstream raw materials:

(2-bromo-4-(trifluoromethyl)phenyl)boronic acid pinacol ester

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