481075-58-5

Basic information

• Product Name: 2-BROMO-1-IODO-4-TRIFLUOROMETHYL-BENZENE
• Synonyms: 2-BROMO-1-IODO-4-TRIFLUOROMETHYL-BENZENE;3-Bromo-4-iodobenzotrifluoride;2-Bromo-1-iodo-4-(trifluoromethyl)benzene, 3-Bromo-4-iodo-alpha,alpha,alpha-trifluorotoluene;3-bromo-4-iodo-trifluoromethylbenzene
• CAS NO: 481075-58-5
• Molecular Formula: C₇H₃BrF₃I
• Molecular Weight: 350.9023996
• Mol File: 481075-58-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 36-38.5℃ (ethanol )
• Boiling Point: 236.9±40.0℃ (760 Torr)
• Flash Point: 97.1±27.3℃
• Appearance: /
• Density: 2.176±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.0709mmHg at 25°C
• Refractive Index: 1.556
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-BROMO-1-IODO-4-TRIFLUOROMETHYL-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-IODO-4-TRIFLUOROMETHYL-BENZENE(481075-58-5)
• EPA Substance Registry System: 2-BROMO-1-IODO-4-TRIFLUOROMETHYL-BENZENE(481075-58-5)

Safety Data

• Hazardous Substances Data: 481075-58-5(Hazardous Substances Data)

Usage

General Description

2-BROMO-1-IODO-4-TRIFLUOROMETHYL-BENZENE is a chemical compound with the molecular formula C7H4BrFI. It is a halogenated aromatic compound that contains bromine, iodine, and trifluoromethyl groups. 2-BROMO-1-IODO-4-TRIFLUOROMETHYL-BENZENE is commonly used in organic synthesis and pharmaceutical research as a building block for creating more complex molecules. Its unique structure and reactivity make it a valuable intermediate for the production of various pharmaceuticals, agrochemicals, and materials. The presence of halogen atoms in the molecule also makes it useful in organic reactions such as nucleophilic substitution and metal-catalyzed cross-coupling reactions. Its diverse applications make 2-BROMO-1-IODO-4-TRIFLUOROMETHYL-BENZENE a valuable tool in the field of organic chemistry and materials science.

InChI:InChI=1/C7H3BrF3I/c8-5-3-4(7(9,10)11)1-2-6(5)12/h1-3H

Upstream product

• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 57946-63-1 4-amino-3-bromobenzotrifluoride 
• 7681-11-0 potassium iodide 

Downstream Products

• 947546-62-5 1-bromo-5-trifluoromethyl-2-(prop-1-ynyl)benzene 
• 947546-73-8 C₁₉H₁₂BrOF₃ 
• 1416800-17-3 4-(2-bromo-4-(trifluoromethyl)phenyl)butanal 
• 85118-24-7 2-bromo-4-(trifluoromethyl)benzaldehyde 
• 773853-91-1 1-bromo-2-(4-chloro-phenylsulfanyl)-5-(trifluoromethyl)-benzene 
• 947546-63-6 C₁₀H₆F₃I 

Relevant articles and documents

5, 10-dihydroindolo [3, 2-b] indole derivative and synthesis method and application thereof

The invention discloses a synthesis method of a 5, 10-dihydroindolo [3, 2-b] indole derivative, the method comprises the following steps: mixing a 2-((2-halogen phenyl) ethynyl)-N, N-dimethylaniline derivative (II), N, N-di-tert-butyl diazacycloketone (III), a palladium catalyst, a monophosphine ligand, alkali and a first organic solvent, and carrying out a diamidation reaction under the protection of inert gas to realize the synthesis of the 5, 10-dihydroindolo [3, 2-b] indole derivative(I). The method is easy to operate, mild in reaction condition and high in reaction yield, and the synthesized 5, 10-dihydroindolo [3, 2-b] indole derivative can be used for preparing an organic light-emitting device.

Palladium-catalyzed three-component approach to promazine with formation of one carbon-sulfur and two carbon-nitrogen bonds

(Chemical Presented) Zip it up! The use of a Pd/dppf catalyst gives access to the tricyclic phenothiazine scaffold starting from 1-bromo-2-iodobenzenes, aliphatic or aromatic amines, and 2-bromothiophenols in a single reaction flask (see scheme; dppf=1,1′-bis(diphenylphosphanyl) ferrocene; dba=dibenzylidineacetone). This transformation involves thioether formation and subsequent intermolecular and intramolecular aryl amination reactions. The reaction occurs in good overall yield and selectivity.

4-(2-PHENYLSULFANYL-PHENYL)-PIPERIDINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS

The invention provides compounds represented by the general formula (I) wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general