4-[6-(Trifluoromethyl)pyrid-2-yl]-1,2,3,6-tetrahydropyridine

Base Information

Chemical Name:4-[6-(Trifluoromethyl)pyrid-2-yl]-1,2,3,6-tetrahydropyridine
CAS No.:335267-11-3
Molecular Formula:C11H11F3N2
Molecular Weight:228.2136496
Hs Code.:
Mol file:335267-11-3.mol

Synonyms:6-(trifluoromethyl)-1',2',3',6'-tetrahydro-2,4'-bipyridine;1′,2′,3′,6′-Tetrahydro-6-(trifluoromethyl)-2,4′-bipyridine;4-[6-(Trifluoromethyl)pyrid-2-yl]-1,2,3,6-tetrahydropyridine

Suppliers and Price of 4-[6-(Trifluoromethyl)pyrid-2-yl]-1,2,3,6-tetrahydropyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 4-[6-(Trifluoromethyl)pyrid-2-yl]-1,2,3,6-tetrahydropyridine

Chemical Property:

Boiling Point:290.8oC at 760 mmHg
Flash Point:129.7oC
PSA：24.92000
Density:1.235g/cm3
LogP:2.80590

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-[6-(Trifluoromethyl)pyrid-2-yl]-1,2,3,6-tetrahydropyridine

There total 3 articles about 4-[6-(Trifluoromethyl)pyrid-2-yl]-1,2,3,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₁₉F₃N₂O₂

: 335267-11-3
6-(trifluoromethyl)-1',2',3',6'-tetrahydro-2,4'-bipyridine

Guidance literature:: With hydrogenchloride; In 1,2-dimethoxyethane; water; at 20 ℃; for 1h;

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 335267-11-3
6-(trifluoromethyl)-1',2',3',6'-tetrahydro-2,4'-bipyridine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 15 h / 80 °C

2: hydrogenchloride / water; 1,2-dimethoxyethane / 1 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water;

Reference yield:

: 189278-27-1
2-bromo-6-(trifluoromethyl)pyridine

: 335267-11-3
6-(trifluoromethyl)-1',2',3',6'-tetrahydro-2,4'-bipyridine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 15 h / 80 °C

2: hydrogenchloride / water; 1,2-dimethoxyethane / 1 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water;