Methyl 5-aMino-4-Methylpyridine-2-carboxylate

Base Information

• Chemical Name: Methyl 5-aMino-4-Methylpyridine-2-carboxylate
• CAS No.: 868551-99-9
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 2933399090
• Mol file: 868551-99-9.mol

Synonyms:Methyl 5-aMino-4-Methylpyridine-2-carboxylate;Methyl 5-aMino-4-Methylpy...;Methyl 5-aMino-4-Methylpicolinate

Chemical Property of Methyl 5-aMino-4-Methylpyridine-2-carboxylate

Chemical Property:

• Boiling Point: 345.9±37.0 °C(Predicted)
• PKA: 3.45±0.10(Predicted)
• PSA: 65.21000
• Density: 1.194±0.06 g/cm3(Predicted)
• LogP: 1.34000
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-Amino-4-methylpyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 5-aMino-4-Methylpyridine-2-carboxylate

There total 2 articles about Methyl 5-aMino-4-Methylpyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-5-nitro-pyridine-2-carboxylic acid methyl ester (868551-30-8) → methyl 5-amino-4-methylpyridine-2-carboxylate (868551-99-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran;

Reference yield:

4-Methyl-5-nitro-pyridin-2-carbonsaeure (5832-43-9) → methyl 5-amino-4-methylpyridine-2-carboxylate (868551-99-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 18 h / Reflux

2: palladium 10% on activated carbon; hydrogen / ethanol / 26 h / 20 °C / 2016.93 - 2327.23 Torr

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In ethanol;

Reference yield: 87.0%

methyl 5-amino-4-methylpyridine-2-carboxylate (868551-99-9) + 2-fluoro-6-[2-(trideuteriomethoxy)-4-(trifluoromethoxy)phenoxy]-3-(trifluoromethyl)benzoyl chloride → methyl 5-[[2-fluoro-6-[2-(trideuteriomethoxy)-4-(trifluoromethoxy)phenoxy]-3-(trifluoromethyl)benzoyl]amino]-4-methylpyridine-2-carboxylate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 18.1667h;

upstream raw materials:

4-methyl-5-nitro-pyridine-2-carboxylic acid methyl ester

4-Methyl-5-nitro-pyridin-2-carbonsaeure

Downstream raw materials:

methyl 1H-pyrazolo[3,4-c]pyridine-5-carboxylate

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