1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 5-chloro-

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 5-chloro-
• CAS No.: 954112-81-3
• Molecular Formula: C₈H₄ClN₃
• Molecular Weight: 177.593
• Hs Code.: 2933990090
• Mol file: 954112-81-3.mol

Synonyms:1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile,5-chloro;5-Chloro-3-cyano-7-azaindole;

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 5-chloro-

Chemical Property:

• PSA: 52.47000
• LogP: 2.08798

Purity/Quality:

97% ^*data from raw suppliers

5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 5-chloro-

There total 4 articles about 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 5-chloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C8H6ClN3O → 5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile (954112-81-3)

Guidance literature:

With trichlorophosphate; Reflux;

DOI:10.1002/ddr.21539

Reference yield: 67.0%

5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde oxime → 5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile (954112-81-3)

Guidance literature:

5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde oxime; With acetic anhydride; for 4h; Heating;

With water; for 3h; Further stages.; Heating;

DOI:10.1016/j.bmc.2007.08.005

Reference yield:

5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde (954112-61-9) → 5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile (954112-81-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride / water / 0.5 h / 60 °C

1.2: 4 h / 100 °C

2.1: trichlorophosphate / Reflux

With hydroxylamine hydrochloride; trichlorophosphate; In water;

DOI:10.1002/ddr.21539

upstream raw materials:

5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde

5-chloro-1H-pyrrolo[2,3-b]pyridine