5-Chloro-7-azaindole

Base Information

• Chemical Name: 5-Chloro-7-azaindole
• CAS No.: 866546-07-8
• Molecular Formula: C7H5ClN2
• Molecular Weight: 152.583
• Hs Code.: 29339900
• Mol file: 866546-07-8.mol

Synonyms:5-Chloro-1H-pyrrolo[2,3-b]pyridine;

Chemical Property of 5-Chloro-7-azaindole

Chemical Property:

• Melting Point: 161-162 °C
• Refractive Index: 1.703
• Boiling Point: 290.5oC at 760 mmHg
• PKA: 12.97±0.40(Predicted)
• Flash Point: 157.1oC
• PSA: 28.68000
• Density: 1.425 g/cm³
• LogP: 2.21630
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

5-Chloro-1H-pyrrolo[2,3-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Chloro-7-azaindole

There total 19 articles about 5-Chloro-7-azaindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

C11H17Cl2NO3 → 5-chloro-1H-pyrrolo[2,3-b]pyridine (866546-07-8)

Guidance literature:

With ammonium hydroxide; sodium hydrogencarbonate; ammonium chloride; In N,N-dimethyl-formamide; at 25 - 70 ℃; for 3h;

Reference yield: 90.0%

5-chloro-2-(triethylsilanyl)-1H-pyrrolo[2,3-b]pyridine (866546-06-7) → 5-chloro-1H-pyrrolo[2,3-b]pyridine (866546-07-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 5h; Molecular sieve 3?;

Reference yield: 88.5%

C9H13Cl2NO3 → 5-chloro-1H-pyrrolo[2,3-b]pyridine (866546-07-8)

Guidance literature:

With ammonium hydroxide; potassium carbonate; ammonium chloride; In tetrahydrofuran; at 25 - 50 ℃; for 5h; Temperature;

upstream raw materials:

2-amino-5-chloro-3-[(trimethylsilyl)ethynyl]pyridine

5-chloro-2-(triethylsilanyl)-1H-pyrrolo[2,3-b]pyridine

5-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine

4-(2-amino-5-chloro-pyridin-3-yl)-2-methyl-but-3-yn-2-ol

Downstream raw materials:

5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde

3-bromo-5-chloro-1 H-pyrrolo[2,3-b]pyridine

3-[(4-benzyloxy-2-fluoro-5-methoxy-phenyl)-methoxy-methyl]-5-chloro-1H-pyrrolo[2,3-b]pyridine

(4-benzyloxy-2-fluoro-5-methoxy-phenyl)-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanol