Bicyclo[4.2.0]octa-1,3,5-triene-7-MethanaMine, 3,4-diMethoxy-N-Methyl-

Base Information

• Chemical Name: Bicyclo[4.2.0]octa-1,3,5-triene-7-MethanaMine, 3,4-diMethoxy-N-Methyl-
• CAS No.: 148870-56-8
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.272
• Mol file: 148870-56-8.mol

Synonyms:(R,S)-1-(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methyl-methanamine;{[(7R,S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}methylamine;[(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]methylamine;4,5-dimethoxy-1-(methylaminomethyl)benzocyclobutane;N-[[3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]-N-methylamine;1-(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methylmethanamine;(+)-N-[(4,5-dimethoxybenzocyclobut-1-yl)methyl]-N-(methyl)amine;

Chemical Property of Bicyclo[4.2.0]octa-1,3,5-triene-7-MethanaMine, 3,4-diMethoxy-N-Methyl-

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Boiling Point: 305.284°C at 760 mmHg
• PKA: 9.94±0.10(Predicted)
• Flash Point: 124.143°C
• PSA: 30.49000
• Density: 1.062g/cm³
• LogP: 1.95380

Purity/Quality:

97% ^*data from raw suppliers

(3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1(6),2,4-TRIEN-7-YLMETHYL)-METHYL-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)-N-methylmethanamine is an impurity of Ivabradine (I940500); Antianginal.

Technology Process of Bicyclo[4.2.0]octa-1,3,5-triene-7-MethanaMine, 3,4-diMethoxy-N-Methyl-

There total 15 articles about Bicyclo[4.2.0]octa-1,3,5-triene-7-MethanaMine, 3,4-diMethoxy-N-Methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.7%

tert-butyl 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbamate (1233201-59-6) → ({3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl)(methyl)amine (148870-56-8)

Guidance literature:

tert-butyl 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbamate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 75 - 80 ℃; for 2.3h;

With water; sodium hydroxide; In tetrahydrofuran; at 0 ℃;

Reference yield: 92.0%

C12H15NO3 → ({3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl)(methyl)amine (148870-56-8)

Guidance literature:

With boron trifluoride-tetrahydrofuran complex; In tetrahydrofuran; at 0 - 20 ℃; for 8h; Temperature; Reagent/catalyst;

Reference yield: 92.0%

ethyl [(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]carbamate (148870-55-7) → ({3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl)(methyl)amine (148870-56-8)

Guidance literature:

ethyl [(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]carbamate; With lithium aluminium tetrahydride; In tetrahydrofuran; for 1.5h; Reflux;

With water; sodium hydroxide; In tetrahydrofuran;

upstream raw materials:

tert-butyl 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbamate

ethyl [(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]carbamate

(2E)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile

3-(3,4-dimethoxyphenyl)propanenitrile

Downstream raw materials:

3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-(methyl)amino]propyl}-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one

ivabradine

[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine

ivabradine hydrochloride