Thieno[2,3-b]pyridine-5-carboxylic acid

Base Information

• Chemical Name: Thieno[2,3-b]pyridine-5-carboxylic acid
• CAS No.: 117390-38-2
• Molecular Formula: C8H5NO2S
• Molecular Weight: 179.199
• Mol file: 117390-38-2.mol

Synonyms:

Chemical Property of Thieno[2,3-b]pyridine-5-carboxylic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thieno[2,3-b]pyridine-5-carboxylic acid

There total 2 articles about Thieno[2,3-b]pyridine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

5-acetyl thieno<2,3-b>pyridine (18354-57-9) → thieno<2,3-b>pyridine-5-carboxylic acid (117390-38-2)

Guidance literature:

With sodium hydroxide; bromine; In water; for 12h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85888-9

Reference yield: 48.0%

5-cyano-thieno<2,3-b>pyridine (21344-31-0) → N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]thieno[2,3-b]pyridine-5-carboxamide Dihydrochloride + thieno<2,3-b>pyridine-5-carboxylic acid (117390-38-2)

Guidance literature:

In sodium hydroxide; ethanol; water;

Reference yield:

thieno<2,3-b>pyridine-5-carboxylic acid (117390-38-2) + 2,4-dimethyl-1-phenylpentan-2-amine → N-(1-benzyl-1,3-dimethylbutyl)thieno[2,3-b]pyridine-5-carboxamide

Guidance literature:

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

5-acetyl thieno<2,3-b>pyridine

5-cyano-thieno<2,3-b>pyridine

Downstream raw materials:

(S)-(-)-N-(thieno<2,3-b>pyridine-5-carbonyl)phenylalaninol

(R)-(+)-N-(thieno<2,3-b>pyridine-5-carbonyl)phenylglycinol

(S)-N-(N-methyl-4,7-dihydrothieno<2,3-b>pyridine-5-carbonyl)phenylalaninol

(S)-(-)-1-methoxy-3-phenyl-N-(thieno<2,3-b>pyridine-5-carbonyl)propane-2-amine

Refernces

• 1、 Cazin, J.,Trefouel, T.,Dupas, G.,Bouguignon, J.,Queguiner, G.. "SYNTHESIS, COMPLEXATION STUDY AND REACTIVITY OF ANNELATED THIOPHENIC NADH MODELS.". . p. 1079 - 1090. Retrieved 2007/10/02.