N4-[(2,5-dimethoxyphenyl)methyl]-N4-methyl-2,8,10-triazabicyclo[4.4.0]deca-2,4,6,8,10-pentaene-4,7,9-triamine

Base Information

• Chemical Name: N4-[(2,5-dimethoxyphenyl)methyl]-N4-methyl-2,8,10-triazabicyclo[4.4.0]deca-2,4,6,8,10-pentaene-4,7,9-triamine
• CAS No.: 175354-76-4
• Molecular Formula: C₁₇H₂₀N₆O₂
• Molecular Weight: 340.385
• Mol file: 175354-76-4.mol

Synonyms:N4-[(2,5-dimethoxyphenyl)methyl]-N4-methyl-2,8,10-triazabicyclo[4.4.0]deca-2,4,6,8,10-pentaene-4,7,9-triamine

Chemical Property of N4-[(2,5-dimethoxyphenyl)methyl]-N4-methyl-2,8,10-triazabicyclo[4.4.0]deca-2,4,6,8,10-pentaene-4,7,9-triamine

Chemical Property:

• Vapor Pressure: 1.03E-16mmHg at 25°C
• Boiling Point: 648.7°Cat760mmHg
• Flash Point: 346.1°C
• PSA: 113.14000
• Density: 1.337g/cm³
• LogP: 2.35410

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N4-[(2,5-dimethoxyphenyl)methyl]-N4-methyl-2,8,10-triazabicyclo[4.4.0]deca-2,4,6,8,10-pentaene-4,7,9-triamine

There total 3 articles about N4-[(2,5-dimethoxyphenyl)methyl]-N4-methyl-2,8,10-triazabicyclo[4.4.0]deca-2,4,6,8,10-pentaene-4,7,9-triamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N6-(2,5-Dimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4,6-triamine → N6-(2,5-Dimethoxy-Benzyl)-N6-MethylPyrido[2,3-D]Pyrimidine-2,4,6-Triamine (175354-76-4)

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride; In acetonitrile; for 4h;

DOI:10.1021/jm950786p

Reference yield:

2,4-diamino-6-nitropyrido<2,3-d>pyrimidine (38944-17-1) → N6-(2,5-Dimethoxy-Benzyl)-N6-MethylPyrido[2,3-D]Pyrimidine-2,4,6-Triamine (175354-76-4)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Raney Ni / dimethylformamide / 3 h / 1810.02 Torr

2: AcOH, H₂ / Raney Ni / dimethylformamide / 3.5 h / 1810.02 Torr

3: 69 percent / NaCNBH₃, conc. HCl / acetonitrile / 4 h

With hydrogenchloride; hydrogen; sodium cyanoborohydride; acetic acid; nickel; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm950786p

Reference yield:

2,4,6-triamino-<2,3-d>pyrimidine (175354-65-1) → N6-(2,5-Dimethoxy-Benzyl)-N6-MethylPyrido[2,3-D]Pyrimidine-2,4,6-Triamine (175354-76-4)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOH, H₂ / Raney Ni / dimethylformamide / 3.5 h / 1810.02 Torr

2: 69 percent / NaCNBH₃, conc. HCl / acetonitrile / 4 h

With hydrogenchloride; hydrogen; sodium cyanoborohydride; acetic acid; nickel; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm950786p

upstream raw materials:

formaldehyd

2,4-diamino-6-nitropyrido<2,3-d>pyrimidine

2,4,6-triamino-<2,3-d>pyrimidine