EMD 534085

Base Information

• Chemical Name: EMD 534085
• CAS No.: 858668-07-2
• Molecular Formula: C₂₅H₃₁F₃N₄O₂
• Molecular Weight: 476.542
• Hs Code.: 2934999090
• Mol file: 858668-07-2.mol

Synonyms:EMD 534085

Chemical Property of EMD 534085

Chemical Property:

• Boiling Point: 609.5±55.0 °C(Predicted)
• PKA: 13.78±0.46(Predicted)
• PSA: 69.12000
• Density: 1.195
• LogP: 5.30260

Purity/Quality:

99%, ^*data from raw suppliers

EMD534085 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of EMD 534085

There total 12 articles about EMD 534085 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

exo-(2R,4aS,5R,10bS)-5-phenyl-9-trifluoromethyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-ylmethylamine (2R,3R)-(-)-di-O-benzoyl tartaric acid salt (1161831-78-2) + N,N-dimethylethylenediamine (108-00-9) → EMD 534085 (858668-07-2)

Guidance literature:

With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 20h; Product distribution / selectivity;

Reference yield: 87.0%

C24H23F3N4O2 + N,N-dimethylethylenediamine (108-00-9) → EMD 534085 (858668-07-2)

Guidance literature:

In dichloromethane; at 25 - 27 ℃; for 15.1667h;

Reference yield: 47.0%

C20H21F3N2O + N,N-dimethylethylenediamine (108-00-9) + 1,1'-carbonyldiimidazole (530-62-1) → C25H31F3N4O2 (858668-07-2)

Guidance literature:

(5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methanamine; 1,1'-carbonyldiimidazole; In dichloromethane; at 40 ℃; for 2h; Inert atmosphere; Sealed tube;

N,N-dimethylethylenediamine; In dichloromethane; at 20 ℃; for 20h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.202115846

upstream raw materials:

N,N-dimethylethylenediamine

exo-(2R,4aS,5R,10bS)-5-phenyl-9-trifluoromethyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-ylmethylamine (2R,3R)-(-)-di-O-benzoyl tartaric acid salt

1-[(R)-1-(3,4-dihydro-2H-pyran-2-yl)methyl]-3-(2-dimethylamino-ethyl)-urea

1-(2-dimethylamino-ethyl)-3-((2R,4aS,5R,10bS)-5-phenyl-9-trifluoromethyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-ylmethyl)-urea

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 858668-07-2 EMD 534085

Send

Send

Metric Ton KG G Pound L ML

Send

Send