N,N-Diethyl-4'-methylbiphenyl-4-carboxamide

Base Information

• Chemical Name: N,N-Diethyl-4'-methylbiphenyl-4-carboxamide
• CAS No.: 957470-88-1
• Molecular Formula: C₁₈H₂₁NO
• Molecular Weight: 267.371
• Mol file: 957470-88-1.mol

Synonyms:N,N-Diethyl-4'-methyl biphenyl-4-carboxamide;

Chemical Property of N,N-Diethyl-4'-methylbiphenyl-4-carboxamide

Chemical Property:

• Melting Point: 68-70℃
• PSA: 20.31000
• LogP: 4.14400

Purity/Quality:

99%,98%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-Diethyl-4'-methylbiphenyl-4-carboxamide

There total 8 articles about N,N-Diethyl-4'-methylbiphenyl-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-chloro-N,N-diethyl-benzamide (7461-38-3) + para-methylphenylmagnesium bromide (4294-57-9) → N,N-diethyl-4′-methylbiphenyl-4-carboxamide (957470-88-1)

Guidance literature:

With ((C₆H₄)(PPh₂)(NCHPhP(O)Ph₂))NiCl; lithium chloride; zinc(II) chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 25 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jo201821g

Reference yield: 99.0%

4-chloro-N,N-diethyl-benzamide (7461-38-3) + p-tolylzinc(II) chloride (90252-89-4) → N,N-diethyl-4′-methylbiphenyl-4-carboxamide (957470-88-1)

Guidance literature:

With Ni(Cl){2-(Ph₂P)C₆H₄NCH(Ph)P(O)Ph₂}; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 25 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c0cc03064c

Reference yield: 99.0%

para-bromotoluene (106-38-7) + 4-chloro-N,N-diethyl-benzamide (7461-38-3) → N,N-diethyl-4′-methylbiphenyl-4-carboxamide (957470-88-1)

Guidance literature:

para-bromotoluene; With lithium;

With zinc(II) chloride;

4-chloro-N,N-diethyl-benzamide; nickel amido phosphine pincer complex; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 70 ℃; for 10h; Further stages.;

DOI:10.1021/ol701927g

upstream raw materials:

para-bromotoluene

4-chloro-N,N-diethyl-benzamide

para-methylphenylmagnesium bromide

4-bromo-N,N-diethylbenzamide

Refernces

• 1、 Wu, Dan,Wang, Zhong-Xia. "P,N,N-Pincer nickel-catalyzed cross-coupling of aryl fluorides and chlorides". . p. 6414 - 6424. Retrieved 2014/08/18.
• 2、 Guo, Wang-Jun,Wang, Zhong-Xia. "Cross-coupling of ArX with ArMgBr catalyzed by N-heterocyclic carbene-based nickel complexes". . p. 1054 - 1061. Retrieved 2013/04/10.