3-Bromo-5-methoxy-benzene-1,2-diamine

Base Information

• Chemical Name: 3-Bromo-5-methoxy-benzene-1,2-diamine
• CAS No.: 98546-54-4
• Molecular Formula: C7H9BrN2O
• Molecular Weight: 217.065
• Hs Code.: 2921490090
• Mol file: 98546-54-4.mol

Synonyms:Reaxys ID: 20605866;2-amino-3-bromo-5-methoxyphenylamine;3-Bromo-5-methoxy-benzene-1,2-diamine;1,2-Benzenediamine, 3-bromo-5-methoxy-

Chemical Property of 3-Bromo-5-methoxy-benzene-1,2-diamine

Chemical Property:

• Boiling Point: 328.2±37.0 °C(Predicted)
• PKA: 2.70±0.10(Predicted)
• PSA: 61.27000
• Density: 1.617±0.06 g/cm3(Predicted)
• LogP: 2.78450

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-5-methoxybenzene-1,2-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Bromo-5-methoxy-benzene-1,2-diamine

There total 1 articles about 3-Bromo-5-methoxy-benzene-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-4-methoxy-6-nitrobenzenamine (10172-35-7) → 3-bromo-5-methoxybenzene-1,2-diamine (98546-54-4)

Guidance literature:

With thiophene; hydrogen; platinum on carbon; In methanol; di-isopropyl ether; at 25 ℃; Inert atmosphere;

Reference yield: 98.0%

3-bromo-5-methoxybenzene-1,2-diamine (98546-54-4) + 4-fluorobenzaldehyde (459-57-4) → C14H10BrFN2O (1239720-36-5)

Guidance literature:

With sodium disulfite; In N,N-dimethyl acetamide; at 90 ℃;

Reference yield:

3-bromo-5-methoxybenzene-1,2-diamine (98546-54-4) → C22H28N2O4S

Guidance literature:

Multi-step reaction with 6 steps

1: triethylamine; sulfur dioxide; aniline / benzene

2: [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl) palladium(II) dichloride; lithium bromide / tetrahydrofuran / 20 °C

3: hydrogen bromide / 130 °C

4: acetic acid; bromine

5: [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl) palladium(II) dichloride; potassium carbonate / tetrahydrofuran / 1.5 h

6: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 - 20 °C

With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl) palladium(II) dichloride; sulfur dioxide; hydrogen bromide; bromine; sodium hydride; potassium carbonate; acetic acid; triethylamine; aniline; lithium bromide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; benzene; 2: |Negishi Coupling / 5: |Suzuki Coupling;

DOI:10.1002/pola.27580

upstream raw materials:

2-bromo-4-methoxy-6-nitrobenzenamine

Downstream raw materials:

C₁₄H₁₀BrFN₂O

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