(S)-5,6,7,8-Tetrahydro-6-(propylamino)-1-naphthalenol hydrobromide

Base Information

• Chemical Name: (S)-5,6,7,8-Tetrahydro-6-(propylamino)-1-naphthalenol hydrobromide
• CAS No.: 165950-84-5
• Molecular Formula: C13H19NO.HBr
• Molecular Weight: 286.21
• Hs Code.: 2922299090
• Mol file: 165950-84-5.mol

Synonyms:(S)-5,6,7,8-TETRAHYDRO-6-(PROPYLAMINO)-1-NAPHTHALENOL HYDROBROMIDE

Chemical Property of (S)-5,6,7,8-Tetrahydro-6-(propylamino)-1-naphthalenol hydrobromide

Chemical Property:

• Vapor Pressure: 0-0Pa at 20-25℃
• PSA: 32.26000
• Density: 1.4g/cm3 at 20℃
• LogP: 3.59810
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99.9% ^*data from raw suppliers

(6S)-6-(Propylamino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-5,6,7,8-Tetrahydro-6-(propylamino)-1-naphthalenol hydrobromide

There total 14 articles about (S)-5,6,7,8-Tetrahydro-6-(propylamino)-1-naphthalenol hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(S)-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propylamine hydrochloride (101403-24-1,3899-07-8) → (S)-1,2,3,4-tetrahydro-5-hydroxy-N-propyl-naphthalen-2-ammonium hydrobromide (165950-84-5,167016-87-7)

Guidance literature:

In hydrogen bromide;

Reference yield: 90.0%

(S)-5-methoxy-2-(N-propylamino)tetralin dibenzoyl-L-tartaric acid salt → (S)-1,2,3,4-tetrahydro-5-hydroxy-N-propyl-naphthalen-2-ammonium hydrobromide (165950-84-5,167016-87-7)

Guidance literature:

(S)-5-methoxy-2-(N-propylamino)tetralin dibenzoyl-L-tartaric acid salt; With sodium hydroxide; In dichloromethane; water; at 10 - 35 ℃; for 0.166667h;

With hydrogen bromide; In water; at 25 - 120 ℃;

Reference yield: 89.0%

(R)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-naphthalen-2-amine (101403-25-2,3899-07-8) → (R)-(+)-5-hydroxy-2-(n-propylamino)tetralin hydrobromide (165950-84-5,167016-87-7)

Guidance literature:

With hydrogen bromide; for 2h; Heating;

upstream raw materials:

(R)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-naphthalen-2-amine

(S)-(-)-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride

(S)-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propylamine hydrochloride

SKF 87967 hydrochloride

Downstream raw materials:

rotigotine hydrochloride

rotigotine

Refernces

• 1、 -. "Novel Process for the Preparation of Nitrogen Substituted Aminotetralins Derivatives". Paragraph 0252-0253. . Retrieved 2013/05/08.
• 2、 -. "NOVEL PROCESS FOR THE PREPARATION OF NITROGEN SUBSTITUTED AMINOTETRALINS DERIVATIVES". Page/Page column 36. . Retrieved 2012/01/13.