2-amino-5-methoxytetralin HCl

Base Information

• Chemical Name: 2-amino-5-methoxytetralin HCl
• CAS No.: 3880-88-4
• Molecular Formula: C11H15 N O . Cl H
• Molecular Weight: 213.707
• Hs Code.: 2922299090
• ChEMBL ID: CHEMBL540116
• DSSTox Substance ID: DTXSID70483987
• Mol file: 3880-88-4.mol

Synonyms:3880-88-4;2-amino-5-methoxytetralin HCl;5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride;5-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine HYDROCHLORIDE;5-methoxy-2-aminotetraline hydrochloride;5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine;hydrochloride;1,2,3,4-Tetrahydro-5-methoxy-2-naphthalenamine hydrochloride;1,2,3,4-Tetrahydro-5-methoxy-2-naphthalenamine HCl;2-amino-5-methoxytetralin Hydrochloride;MFCD08443937;AC-055;5-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine(1HClsalt);2-Naphthalenamine, 1,2,3,4-tetrahydro-5-methoxy-, hydrochloride;SKF 87967 hydrochloride;CHEMBL540116;SCHEMBL6824058;DTXSID70483987;CGLCAQWQPIFKRX-UHFFFAOYSA-N;MFCD08544193;5-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINEHYDROCHLORIDE;AKOS024257160;SB36968;PD016909;SY113340;CS-0119513;FT-0659104;FT-0750318;EN300-8667715;2-Amino-5-Methoxy-1,2,3,4-Tetrahydronaphthalene HCl;5-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylamine HCl;Z2574933282;(S)-2-Amino-5-methoxy-1,2,3,4-tetrahydronaphthalene Hydrochloride;5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride (1:1)

Chemical Property of 2-amino-5-methoxytetralin HCl

Chemical Property:

• Vapor Pressure: 5.8E-05mmHg at 25°C
• Boiling Point: 341.2°C at 760 mmHg
• Flash Point: 160.2°C
• PSA: 35.25000
• LogP: 3.01350
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 213.0920418
• Heavy Atom Count: 14
• Complexity: 172

Purity/Quality:

98%Min ^*data from raw suppliers

5-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylaminehydrochloride 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC2=C1CCC(C2)N.Cl

Technology Process of 2-amino-5-methoxytetralin HCl

There total 10 articles about 2-amino-5-methoxytetralin HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

benzyl 5-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (1309876-80-9) → SKF 87967 hydrochloride (3880-88-4,58349-15-8,58349-17-0)

Guidance literature:

With chloroform; palladium on carbon; hydrogen; In methanol; at 20 ℃; for 24h;

DOI:10.1080/00397911.2010.495043

Reference yield: 62.0%

→ SKF 87967 hydrochloride (3880-88-4,58349-15-8,58349-17-0)

Guidance literature:

Reference yield:

5-methoxy-2-tetralone (32940-15-1) → SKF 87967 hydrochloride (3880-88-4,58349-15-8,58349-17-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 g / 1 N NaOH / ethanol; H₂O / pH 8.2

2: 1.) B₂H₆, 2.) concd. HCl / 1.) THF, reflux, 3 h, 2.) reflux, 15 min

With hydrogenchloride; sodium hydroxide; diborane; In ethanol; water;

DOI:10.1021/jm00344a009

upstream raw materials:

5-Methoxy-3,4-dihydro-1H-naphthalen-2-one O-methyl-oxime

5-methoxy-2-tetralone

benzyl 5-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate

5-bromo-2-naphthalenecarboxylic acid methyl ester

Downstream raw materials:

(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride

rotigotine

(S)-1,2,3,4-tetrahydro-5-hydroxy-N-propyl-naphthalen-2-ammonium hydrobromide

rotigotine hydrochloride

Refernces

• 1、 -. "Substituted amino-5,6,7,8-tetrahydronaphthyl-oxyacetic acids, processes for their preparation and their use as medicaments". . . Retrieved 2008/06/13.