Desthienylethyl rotigotine

Base Information

Chemical Name:Desthienylethyl rotigotine
CAS No.:101470-23-9
Molecular Formula:C13H19NO
Molecular Weight:205.3
Hs Code.:2922299090
European Community (EC) Number:800-424-3
UNII:S0A0O2B54C
DSSTox Substance ID:DTXSID30436893
Wikidata:Q27288390
Mol file:101470-23-9.mol

Synonyms:101470-23-9;Desthienylethyl rotigotine;(6S)-5,6,7,8-Tetrahydro-6-(propylamino)-1-naphthalenol;(-)-5-Hydroxy-N-n-propyl-2-aminotetralin;1-Naphthalenol, 5,6,7,8-tetrahydro-6-(propylamino)-, (6S)-;UNII-S0A0O2B54C;S0A0O2B54C;(S)-6-(Propylamino)-5,6,7,8-tetrahydronaphthalen-1-ol;(6S)-(-)-5-Hydroxy-N-propyl-2-aminotetralin;(6S)-6-(PROPYLAMINO)-5,6,7,8-TETRAHYDRONAPHTHALEN-1-OL;(S)-(-)-5-Hydroxy-N-n-propyl-2-aminotetralin;SCHEMBL1682783;DTXSID30436893;VCYPZWCFSAHTQT-NSHDSACASA-N;AKOS022174929;ROTIGOTINE IMPURITY B [EP IMPURITY];(S)-5,6,7,8-tetrahydro-6-propylamino-1-naphthol;J-000401;(S)-6-propylamino-5,6,7,8-tetrahydro-l-naphthalenol;Q27288390;(-)-(6-PROPYLAMINO)-5,6,7,8-TETRAHYDRO-NAPHTHALEN-1-OL

Suppliers and Price of Desthienylethyl rotigotine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(6S)-5,6,7,8-Tetrahydro-6-(propylamino)-1-naphthalenol
50 mg
$ 225.00

TRC
(6S)-5,6,7,8-Tetrahydro-6-(propylamino)-1-naphthalenol
10mg
$ 85.00

Crysdot
(S)-6-(Propylamino)-5,6,7,8-tetrahydronaphthalen-1-ol 95+%
1g
$ 672.00

Chemenu
(S)-6-(propylamino)-5,6,7,8-tetrahydronaphthalen-1-ol 95%
1g
$ 635.00

American Custom Chemicals Corporation
(-)-(6-PROPYLAMINO)-5,6,7,8-TETRAHYDRO-NAPHTHALEN-1-OL 95.00%
1G
$ 1229.55

American Custom Chemicals Corporation
(-)-(6-PROPYLAMINO)-5,6,7,8-TETRAHYDRO-NAPHTHALEN-1-OL 95.00%
5MG
$ 496.14

Alichem
(S)-6-(Propylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
1g
$ 601.70

Total 13 raw suppliers

Chemical Property of Desthienylethyl rotigotine

Chemical Property:

Boiling Point:341.5±42.0 °C(Predicted)
PKA:9.96±0.20(Predicted)
PSA：32.26000
Density:1.07±0.1 g/cm3(Predicted)
LogP:2.64000
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:205.146664230
Heavy Atom Count:15
Complexity:195

Purity/Quality:

98%min ^*data from raw suppliers

(6S)-5,6,7,8-Tetrahydro-6-(propylamino)-1-naphthalenol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCNC1CCC2=C(C1)C=CC=C2O
Isomeric SMILES:CCCN[C@H]1CCC2=C(C1)C=CC=C2O
Uses A substituted tetralin used in the production of antiparkinson medications As a substituted tetralin, (6S)-5,6,7,8-Tetrahydro-6-(propylaMino)-1-naphthalenol is used in the production of antiparkinson medications

Technology Process of Desthienylethyl rotigotine

There total 14 articles about Desthienylethyl rotigotine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1222074-04-5
(S)-(-)-2-(N-propylamino)-5-hydroxytetraline (-)-N-(3,5-dinitrobenzoyl)-α-phenylglycine salt

: 101470-23-9
Desthienyl-Rotigotine

Guidance literature:: With potassium carbonate; In toluene; at 60 ℃;

Reference yield: 97.0%

: 101403-24-1,3899-07-8
(S)-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propylamine hydrochloride

: 101470-23-9
Desthienyl-Rotigotine

Guidance literature:: (S)-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propylamine hydrochloride; With boron tribromide; In dichloromethane; at -40 - 20 ℃;

With water; sodium hydrogencarbonate; In dichloromethane;
DOI:10.1021/ol1022239

Reference yield: 90.0%

: 165950-84-5,167016-87-7
(S)-1,2,3,4-tetrahydro-5-hydroxy-N-propyl-naphthalen-2-ammonium hydrobromide

: 101470-23-9
Desthienyl-Rotigotine

Guidance literature:: (S)-1,2,3,4-tetrahydro-5-hydroxy-N-propyl-naphthalen-2-ammonium hydrobromide; With sodium hydroxide; In water; at 40 ℃; pH=12.5;

With hydrogenchloride; In water; pH=9 - 9.5;