(S)-(-)-2-(N-propylamino)-5-hydroxytetraline (-)-N-(3,5-dinitrobenzoyl)-α-phenylglycine salt

Base Information

• Chemical Name: (S)-(-)-2-(N-propylamino)-5-hydroxytetraline (-)-N-(3,5-dinitrobenzoyl)-α-phenylglycine salt
• CAS No.: 1222074-04-5
• Molecular Formula: C₁₃H₁₉NO*C₁₅H₁₁N₃O₇
• Molecular Weight: 550.568
• Mol file: 1222074-04-5.mol

Synonyms:(S)-(-)-2-(N-propylamino)-5-hydroxytetraline (-)-N-(3,5-dinitrobenzoyl)-α-phenylglycine salt

Chemical Property of (S)-(-)-2-(N-propylamino)-5-hydroxytetraline (-)-N-(3,5-dinitrobenzoyl)-α-phenylglycine salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(-)-2-(N-propylamino)-5-hydroxytetraline (-)-N-(3,5-dinitrobenzoyl)-α-phenylglycine salt

There total 1 articles about (S)-(-)-2-(N-propylamino)-5-hydroxytetraline (-)-N-(3,5-dinitrobenzoyl)-α-phenylglycine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

2-N-propylamino-1,2,3,4-tetrahydro-5-hydroxynaphthalene (78950-82-0) + (R)-(-)-N-(3,5-dinitrobenzoyl)-α-phenylglycine (74927-72-3) → (S)-(-)-2-(N-propylamino)-5-hydroxytetraline (-)-N-(3,5-dinitrobenzoyl)-α-phenylglycine salt (1222074-04-5)

Guidance literature:

In water; acetonitrile; at 0 - 5 ℃; Heating; Resolution of racemate;

Reference yield: 98.0%

(S)-(-)-2-(N-propylamino)-5-hydroxytetraline (-)-N-(3,5-dinitrobenzoyl)-α-phenylglycine salt (1222074-04-5) → Desthienyl-Rotigotine (101470-23-9)

Guidance literature:

With potassium carbonate; In toluene; at 60 ℃;

Reference yield:

(S)-(-)-2-(N-propylamino)-5-hydroxytetraline (-)-N-(3,5-dinitrobenzoyl)-α-phenylglycine salt (1222074-04-5) → rotigotine (99755-59-6,112835-48-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / toluene / 60 °C

2.1: sodium hydrogencarbonate / acetonitrile / 9 h / Reflux

2.2: pH 1 - 2

2.3: pH 7 - 7.5

With sodium hydrogencarbonate; potassium carbonate; In toluene; acetonitrile;

upstream raw materials:

2-N-propylamino-1,2,3,4-tetrahydro-5-hydroxynaphthalene

(R)-(-)-N-(3,5-dinitrobenzoyl)-α-phenylglycine

Downstream raw materials:

Desthienyl-Rotigotine

rotigotine