GSK-3beta Inhibitor XI

Base Information

Chemical Name:GSK-3beta Inhibitor XI
CAS No.:626604-39-5
Molecular Formula:C18H15N5O3
Molecular Weight:349.34
Hs Code.:
DSSTox Substance ID:DTXSID20434343
Wikidata:Q27077901
Pharos Ligand ID:PG7NFYF2WNH2
ChEMBL ID:CHEMBL272629
Mol file:626604-39-5.mol

Synonyms:GSK-3beta Inhibitor XI;626604-39-5;GSK-3b inhibitor XI;CHEMBL272629;3-[1-(3-hydroxypropyl)pyrrolo[2,3-b]pyridin-3-yl]-4-pyrazin-2-ylpyrrole-2,5-dione;GSK3?? Inhibitor XI;D02ZIY;GSK-3 beta Inhibitor XI;SCHEMBL462891;GTPL5981;DTXSID20434343;HMS3229G22;BDBM50371955;AKOS040755038;CCG-206846;Q27077901;4-(1-(3-hydroxypropyl)-1h-pyrrolo[2,3-b]pyridin-3-yl)-3-(pyrazin-2-yl)pyrrole-2,5-dione;3-(1-(3-Hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-pyrazin-2-yl-pyrrole-2,5-dione, 7AIPM;3-[1-(3-hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-(pyrazin-2-yl)-2,5-dihydro-1H-pyrrole-2,5-dione

Suppliers and Price of GSK-3beta Inhibitor XI

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
GSK3β Inhibitor XI ≥98%
1mg
$ 187.00

American Custom Chemicals Corporation
GSK-3BETA INHIBITOR XI 95.00%
1MG
$ 705.82

AK Scientific
GSK-3betaInhibitorxi
1mg
$ 332.00

aablocks
GSK-3βInhibitorXI ≥98%
1mg
$ 265.00

Total 12 raw suppliers

Chemical Property of GSK-3beta Inhibitor XI

Chemical Property:

PSA：113.49000
LogP:1.05180
XLogP3:-0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:349.11748936
Heavy Atom Count:26
Complexity:608

Purity/Quality:

99% ^*data from raw suppliers

GSK3β Inhibitor XI ≥98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(N=C1)N(C=C2C3=C(C(=O)NC3=O)C4=NC=CN=C4)CCCO

Technology Process of GSK-3beta Inhibitor XI

There total 7 articles about GSK-3beta Inhibitor XI which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 626604-39-5
GSK-3b Inhibitor XI

Guidance literature:

Reference yield:

: 626605-07-0
2-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-acetamide

: 626604-39-5
GSK-3b Inhibitor XI

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / potassium tert-butoxide / tetrahydrofuran / 0.33 h

2: 73 percent / oxalyl chloride / CH₂Cl₂; dimethylformamide / 1 h / 23 °C

3: Pd(P(t-Bu)3)2 / tetrahydrofuran / 18 h / Heating

4: TBAF / tetrahydrofuran / 18 h

With oxalyl dichloride; potassium tert-butylate; tetrabutyl ammonium fluoride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: Stille cross-coupling;
DOI:10.1016/j.bmc.2004.04.010

Reference yield:

: 626605-09-2
3-{1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-4-chloro-pyrrole-2,5-dione

: 626604-39-5
GSK-3b Inhibitor XI

Guidance literature:: Multi-step reaction with 2 steps

1: Pd(P(t-Bu)3)2 / tetrahydrofuran / 18 h / Heating

2: TBAF / tetrahydrofuran / 18 h

With tetrabutyl ammonium fluoride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1: Stille cross-coupling;
DOI:10.1016/j.bmc.2004.04.010